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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Tory M. Schaff, Lei Zhang, Maria Zagorulya, Greg Tombline, Michael Gilbert, Samantha L. Yuen, Alexis Pope, Michael Van Meter, View ORCID ProfileStephan Emmrich, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin A. Garcia, David D. Thomas, Paul D. Robbins, Jan Vijg, Andrei Seluanov, Yousin Suh, View ORCID ProfileVera Gorbunova
doi: https://doi.org/10.1101/2021.12.13.472381
Matthew Simon
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Jiping Yang
2Department of Obstetrics and Gynecology, Columbia University; New York, NY 10032, USA
Jonathan Gigas
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Eric J. Earley
3Biostatistics and Epidemiology, RTI International, Durham, NC, USA
Tory M. Schaff
4Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism, University of Minnesota; Minneapolis, MN 55455
Lei Zhang
4Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism, University of Minnesota; Minneapolis, MN 55455
Maria Zagorulya
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Greg Tombline
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Michael Gilbert
5Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
Samantha L. Yuen
4Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism, University of Minnesota; Minneapolis, MN 55455
Alexis Pope
2Department of Obstetrics and Gynecology, Columbia University; New York, NY 10032, USA
Michael Van Meter
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Stephan Emmrich
1Department of Biology, University of Rochester; Rochester NY 14627, USA
Jeehae Han
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Seungjin Ryu
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Archana Tare
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Yizhou Zhu
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Adam Hudgins
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Gil Atzmon
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
7Department of Biology, Faculty of Natural Sciences, University of Haifa; Haifa, Israel 31905
Nir Barzilai
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Aaron Wolfe
8Ichor Therapeutics; 2521 US-11, Lafayette, NY 13084, USA
Kelsey Moody
8Ichor Therapeutics; 2521 US-11, Lafayette, NY 13084, USA
Benjamin A. Garcia
5Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA
David D. Thomas
4Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism, University of Minnesota; Minneapolis, MN 55455
Paul D. Robbins
4Department of Biochemistry, Molecular Biology and Biophysics and Institute on the Biology of Aging and Metabolism, University of Minnesota; Minneapolis, MN 55455
Jan Vijg
6Department of Genetics, Albert Einstein College of Medicine; Bronx, NY, USA
Andrei Seluanov
2Department of Obstetrics and Gynecology, Columbia University; New York, NY 10032, USA
Yousin Suh
3Biostatistics and Epidemiology, RTI International, Durham, NC, USA
Vera Gorbunova
2Department of Obstetrics and Gynecology, Columbia University; New York, NY 10032, USA
Article usage
Posted December 13, 2021.
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Tory M. Schaff, Lei Zhang, Maria Zagorulya, Greg Tombline, Michael Gilbert, Samantha L. Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin A. Garcia, David D. Thomas, Paul D. Robbins, Jan Vijg, Andrei Seluanov, Yousin Suh, Vera Gorbunova
bioRxiv 2021.12.13.472381; doi: https://doi.org/10.1101/2021.12.13.472381
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley, Tory M. Schaff, Lei Zhang, Maria Zagorulya, Greg Tombline, Michael Gilbert, Samantha L. Yuen, Alexis Pope, Michael Van Meter, Stephan Emmrich, Jeehae Han, Seungjin Ryu, Archana Tare, Yizhou Zhu, Adam Hudgins, Gil Atzmon, Nir Barzilai, Aaron Wolfe, Kelsey Moody, Benjamin A. Garcia, David D. Thomas, Paul D. Robbins, Jan Vijg, Andrei Seluanov, Yousin Suh, Vera Gorbunova
bioRxiv 2021.12.13.472381; doi: https://doi.org/10.1101/2021.12.13.472381
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