New Results
Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection
Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Krähling, Michelle Gellhorn-Serra, View ORCID ProfileChristoph Kreer, Michael Klüver, Lucie Sauerhering, Jörg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, View ORCID ProfileMarek Widera, Manuel Koch, Anke Werner, Lennart Kämper, Nico Becker, Michael S Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker
doi: https://doi.org/10.1101/2021.06.09.447662
Sandro Halwe
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Alexandra Kupke
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Kanika Vanshylla
3Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
Falk Liberta
6Biotherapeutics Discovery, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach an der Riss, Germany
Henning Gruell
3Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
Matthias Zehner
3Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
Cornelius Rohde
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Verena Krähling
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Michelle Gellhorn-Serra
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Christoph Kreer
3Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
Michael Klüver
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Lucie Sauerhering
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Jörg Schmidt
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Zheng Cai
7Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Fei Han
7Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
David Young
7Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Guangwei Yang
7Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Marek Widera
8Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt am Main, 60596, Germany
Manuel Koch
5Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany
11Institute for Dental Research and Oral Musculoskeletal Biology and Center for Biochemistry, University of Cologne, 50931 Cologne, Germany
Anke Werner
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
Lennart Kämper
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
Nico Becker
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
Michael S Marlow
7Biotherapeutics Molecule Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA
Markus Eickmann
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
Sandra Ciesek
8Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt am Main, 60596, Germany
9German Center for Infection Research (DZIF), partner site Frankfurt am Main, Germany
10Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Frankfurt am Main, 60596, Germany
Felix Schiele
6Biotherapeutics Discovery, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397 Biberach an der Riss, Germany
Florian Klein
3Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany
4German Center for Infection Research (DZIF), partner Site Bonn-Cologne, 50931 Cologne, Germany
5Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany
Stephan Becker
1Institute of Virology, Philipps University Marburg, Hans-Meerwein-Straße 2, 35043 Marburg, Germany
2German Center for Infection Research (DZIF), partner site Giessen-Marburg-Langen, Marburg, Germany
Posted June 09, 2021.
Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection
Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Krähling, Michelle Gellhorn-Serra, Christoph Kreer, Michael Klüver, Lucie Sauerhering, Jörg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, Marek Widera, Manuel Koch, Anke Werner, Lennart Kämper, Nico Becker, Michael S Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker
bioRxiv 2021.06.09.447662; doi: https://doi.org/10.1101/2021.06.09.447662
Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection
Sandro Halwe, Alexandra Kupke, Kanika Vanshylla, Falk Liberta, Henning Gruell, Matthias Zehner, Cornelius Rohde, Verena Krähling, Michelle Gellhorn-Serra, Christoph Kreer, Michael Klüver, Lucie Sauerhering, Jörg Schmidt, Zheng Cai, Fei Han, David Young, Guangwei Yang, Marek Widera, Manuel Koch, Anke Werner, Lennart Kämper, Nico Becker, Michael S Marlow, Markus Eickmann, Sandra Ciesek, Felix Schiele, Florian Klein, Stephan Becker
bioRxiv 2021.06.09.447662; doi: https://doi.org/10.1101/2021.06.09.447662
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