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Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome
Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Makoto Sahara, Alexander Goedel, Andreas Dendorfer, Fleur V.Y. Tjong, Maria E. Rijlaarsdam, Julie Cleuziou, Nora Lang, Christian Kupatt, Connie Bezzina, Rüdiger Lange, Neil E. Bowles, Matthias Mann, Bruce Gelb, Lia Crotti, Lutz Hein, Thomas Meitinger, Sean Wu, Daniel Sinnecker, Peter J. Gruber, Karl-Ludwig Laugwitz, View ORCID ProfileAlessandra Moretti
doi: https://doi.org/10.1101/2021.04.24.441110
Markus Krane
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
MDMartina Dreßen
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
PhDGianluca Santamaria
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
PhDIlaria My
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDChristine M. Schneider
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDTatjana Dorn
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
PhDSvenja Laue
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
PhDElisa Mastantuono
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
4Institute of Human Genetics, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany, and Helmholtz Zentrum München, Ingolstaedter Landstra(e 1, 85764 Neuherberg, Germany
MDRiccardo Berutti
4Institute of Human Genetics, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany, and Helmholtz Zentrum München, Ingolstaedter Landstra(e 1, 85764 Neuherberg, Germany
PhDHilansi Rawat
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MSRalf Gilsbach
5Institute of Experimental and Clinical Pharmacology and Toxicology University of Freiburg Albertstrasse 25, 79104 Freiburg, Germany
6Institute for Cardiovascular Physiology, Goethe University, Frankfurt am Main, Germany
7DZHK (German Centre for Cardiovascular Research) - partner site RheinMain, Frankfurt am Main, Germany
PhDPedro Schneider
5Institute of Experimental and Clinical Pharmacology and Toxicology University of Freiburg Albertstrasse 25, 79104 Freiburg, Germany
MDHarald Lahm
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
PhDSascha Schwarz
8Center for Applied Tissue Engineering and Regenerative Medicine (CANTER), Munich University of Applied Sciences, Lothstr. 34, 80335 Munich, Germany
MSStefanie A. Doppler
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
PhDSharon Paige
9Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
MD, PhDNazan Puluca
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
MDSophia Doll
10Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany
PhDIrina Neb
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
MSThomas Brade
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
PhDZhong Zhang
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
Claudia Abou-Ajram
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
Bernd Northoff
11Institute of Laboratory Medicine, University Hospital, LMU Munich, Marchioninistra(e 15, 81377 Munich, Germany.
MSLesca M. Holdt
11Institute of Laboratory Medicine, University Hospital, LMU Munich, Marchioninistra(e 15, 81377 Munich, Germany.
MDStefanie Sudhop
8Center for Applied Tissue Engineering and Regenerative Medicine (CANTER), Munich University of Applied Sciences, Lothstr. 34, 80335 Munich, Germany
PhDMakoto Sahara
12Department of Cell and Molecular Biology, Karolinska Institute, Stockholm 171 77, Sweden
MDAlexander Goedel
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDAndreas Dendorfer
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
13Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, Marchioninistr. 27, 81377 Munich, Germany
MDFleur V.Y. Tjong
14Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, 1105 AZ Amsterdam, The Netherlands
MD, PhDMaria E. Rijlaarsdam
15Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, The Netherlands
MDJulie Cleuziou
16Department of Congenital and Paediatric Heart Surgery, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
MDNora Lang
17Department of Paediatric Cardiology and Congenital Heart Defects, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
MDChristian Kupatt
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDConnie Bezzina
14Department of Clinical and Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Centre, 1105 AZ Amsterdam, The Netherlands
MDRüdiger Lange
1Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, Technical University of Munich, Lazarettstrasse 36, 80636 Munich, Germany
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
MDNeil E. Bowles
18Department of Pediatrics (Division of Cardiology), University of Utah School of Medicine, Salt Lake City, UT, USA
PhDMatthias Mann
10Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany
PhDBruce Gelb
19The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
MDLia Crotti
20Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, 22 Via Pier Lombardo, Milan, Italy
21Istituto Auxologico Italiano, IRCCS, Cardiomyopathies Unit, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Milan, Italy
22Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
MDLutz Hein
5Institute of Experimental and Clinical Pharmacology and Toxicology University of Freiburg Albertstrasse 25, 79104 Freiburg, Germany
23BIOSS, Center for Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany
MDThomas Meitinger
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
4Institute of Human Genetics, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany, and Helmholtz Zentrum München, Ingolstaedter Landstra(e 1, 85764 Neuherberg, Germany
PhDSean Wu
9Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
MDDaniel Sinnecker
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDPeter J. Gruber
24Department of Surgery, Yale University, New Haven, CT, USA
MD, PhDKarl-Ludwig Laugwitz
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
MDAlessandra Moretti
2DZHK (German Centre for Cardiovascular Research) - partner site Munich Heart Alliance, Munich, Germany
3First Department of Medicine, Cardiology, Klinikum rechts der Isar - Technical University of Munich, Ismaninger Stra(e 22, 81675 Munich, Germany
PhDArticle usage
Posted April 26, 2021.
Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome
Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Makoto Sahara, Alexander Goedel, Andreas Dendorfer, Fleur V.Y. Tjong, Maria E. Rijlaarsdam, Julie Cleuziou, Nora Lang, Christian Kupatt, Connie Bezzina, Rüdiger Lange, Neil E. Bowles, Matthias Mann, Bruce Gelb, Lia Crotti, Lutz Hein, Thomas Meitinger, Sean Wu, Daniel Sinnecker, Peter J. Gruber, Karl-Ludwig Laugwitz, Alessandra Moretti
bioRxiv 2021.04.24.441110; doi: https://doi.org/10.1101/2021.04.24.441110
Sequential defects in cardiac lineage commitment and maturation cause hypoplastic left heart syndrome
Markus Krane, Martina Dreßen, Gianluca Santamaria, Ilaria My, Christine M. Schneider, Tatjana Dorn, Svenja Laue, Elisa Mastantuono, Riccardo Berutti, Hilansi Rawat, Ralf Gilsbach, Pedro Schneider, Harald Lahm, Sascha Schwarz, Stefanie A. Doppler, Sharon Paige, Nazan Puluca, Sophia Doll, Irina Neb, Thomas Brade, Zhong Zhang, Claudia Abou-Ajram, Bernd Northoff, Lesca M. Holdt, Stefanie Sudhop, Makoto Sahara, Alexander Goedel, Andreas Dendorfer, Fleur V.Y. Tjong, Maria E. Rijlaarsdam, Julie Cleuziou, Nora Lang, Christian Kupatt, Connie Bezzina, Rüdiger Lange, Neil E. Bowles, Matthias Mann, Bruce Gelb, Lia Crotti, Lutz Hein, Thomas Meitinger, Sean Wu, Daniel Sinnecker, Peter J. Gruber, Karl-Ludwig Laugwitz, Alessandra Moretti
bioRxiv 2021.04.24.441110; doi: https://doi.org/10.1101/2021.04.24.441110
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