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- April 24, 2017.
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Author Information
- Angel C. Y. Mak1#*,
- Marquitta J. White1#,
- Zachary A. Szpiech2#,
- Walter L. Eckalbar1,
- Sam S. Oh1,
- Maria Pino-Yanes3,4,
- Donglei Hu1,
- Scott Huntsman1,
- Joshua Galanter1,
- Dara G. Torgerson1,
- Ann Chen Wu5,6,
- Blanca E. Himes7,
- Soren Germer8,
- Julia M. Vogel8,
- Karen L. Bunting8,
- Celeste Eng1,
- Sandra Salazar1,
- Kevin L. Keys1,
- Thomas A. Nguyen1,
- Pui-Yan Kwok9,10,
- Albert M. Levin11,
- Juan C. Celedón12,
- Erick Forno12,
- Hakon Hakonarson13,14,
- Patrick M. Sleiman13,14,
- Amber Dahlin5,
- Kelan G. Tantisira5,
- Scott T. Weiss5,
- Denise Serebrisky15,
- Emerita Brigino-Buenaventura16,
- Harold J. Farber17,
- Kelley Meade18,
- Michael A. Lenoir19,
- Pedro C. Avila20+,
- Saunak Sen1,
- Shannon M. Thyne21,
- William Rodriguez-Cintron22,
- Cheryl A. Winkler23,
- Andrés Moreno-Estrada24,
- Karla Sandoval24,
- Jose R. Rodriguez-Santana25,
- Rajesh Kumar26,27,
- L. Keoki Williams28,29,
- Nadav Ahituv1,
- Elad Ziv1,
- Max A. Seibold30,
- Robert B. Darnell8,31,32,
- Noah Zaitlen1,
- Ryan D. Hernandez2,10,33,
- Esteban G. Burchard1,
- the Trans-Omics for Precision Medicine Whole Genome Sequencing Program (TOPMed) Team These authors contributed equally to this work
- 1Department of Medicine, University of California San Francisco, San Francisco, California, USA.
- 2Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.
- 3Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
- 4CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
- 5Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA.
- 6Precision Medicine Translational Research (PRoMoTeR) Center, Department of Population Medicine, Harvard Medical School and Pilgrim Health Care Institute, Boston, Massachusetts, USA.
- 7Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 8New York Genome Center, New York, New York, USA.
- 9Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
- 10Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA.
- 11Department of Public Health Sciences, Henry Ford Health System, Detroit Michigan, USA.
- 12Division of Pediatric Pulmonary Medicine, Allergy and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
- 13Center for Applied Genomics, The Children’s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania, USA.
- 14Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
- 15Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, New York, USA.
- 16Department of Allergy and Immunology, Kaiser Permanente Vallejo Medical Center, Vallejo, California, USA.
- 17Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA.
- 18Children’s Hospital and Research Center, Oakland, California, USA.
- 19Bay Area Pediatrics, Oakland, California, USA.
- 20Department of Medicine, Northwestern University, Chicago, Illinois, USA.
- 21Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
- 22Veterans Caribbean Health Care System, San Juan, Puerto Rico.
- 23Basic Science Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Frederick National Laboratory, Frederick, Maryland, USA.
- 24National Laboratory of Genomics for Biodiversity (UGA-LANGEBIO), CINVESTAV, Irapuato, Guanajuato, Mexico.
- 25Centro de Neumologia Pediatrica, San Juan, Puerto Rico.
- 26Feinberg School of Medicine’s Division of Allergy and Immunology, Northwestern University, Chicago, Illinois, USA.
- 27Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA.
- 28Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.
- 29Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan, USA.
- 30Center for Genes, Environment and Health, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
- 31Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York, USA.
- 32Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA.
- 33Quantitative Biosciences Institute, University of California San Francisco, San Francisco, California, USA.
- ↵*Correspondence and material requests should be addressed to Angel C.Y. Mak (angel.mak{at}ucsf.edu)
↵# These authors contributed equally to this work
AUTHOR CONTRIBUTIONS A.C.Y.M., M.J.W., Z.A.S., D.H., M.P.-Y., J.G. and S.H. analyzed data. R.D.H., N.Z., M.A.S., E.G.B., D.G.T., M.J.W., A.C.Y.M., N.A., E.Z., R.B.D. and P.-Y.K. designed experiments or supervised research. A.C.Y.M., M.J.W., Z.A.S., S.S.O., M.P.-Y., E.G.B. and K.L.K. prepared tables and figures, and wrote the manuscript. C.E., S.G., K.L.B. and J.M.W. generated data and supervised data generation. W.E., T.N. and B.E.H. performed validation experiments and analyses. M.J.W., M.P.-Y., L.K.W., A.M.L., J.C.C., E.F., H.H., P.M.S., A.C.W., A.D., K.G.T. and S.T.W. performed replication analyses. E.G.B., D.S., E.B.B., H.J.F., J.R.R.-S., K.M., M.A.L., P.C.A., R.K., S. Sen, S.T. and W.R.-C. recruited study subjects. S. Salazar coordinated recruitment and maintained phenotype data quality. C.A.W., A.M.-E. and K.S. contributed Native American samples. TOPMed team provided variants annotation.