Article Information
History
- August 9, 2016.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Author Information
- Antonio F. Pardiñasa,
- Peter Holmansa,
- Andrew J. Pocklingtona,
- Valentina Escott-Pricea,
- Stephan Ripkeb,c,
- Noa Carreraa,
- Sophie E. Leggea,
- Sophie Bishopa,
- Darren Camerona,
- Marian L. Hamsherea,
- Jun Hana,
- Leon Hubbarda,
- Amy Lynhama,
- Kiran Mantripragadaa,
- Elliott Reesa,
- James H. MacCabed,
- Steven A. McCarrolle,
- Bernhard T. Baunef,
- Gerome Breeng,h,
- Enda M. Byrnei,
- Udo Dannlowskij,k,
- Thalia C. Eleyg,
- Caroline Haywardl,
- Nicholas G. Martinm,n,
- Andrew M. McIntosho,p,
- Robert Ploming,
- David J. Porteousl,
- Naomi R. Wrayi,
- GERAD Consortiumq,
- David A. Collierg,r,
- Dan Rujescus,t,
- George Kirova,
- Michael J. Owena,*,
- Michael C. O’Donovana,* and
- James T. R. Waltersa,*
- aMRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK
- bAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
- cDepartment of Psychiatry and Psychotherapy, Charité, Campus Mitte, 10117 Berlin, Germany
- dDepartment of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King’s College London
- eStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
- fDiscipline of Psychiatry, University of Adelaide, Australia
- gMedical Research Council, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
- hNIHR Biomedical Research Centre for Mental Health, Maudsley Hospital and Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
- iQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia
- jDepartment of Psychiatry and Psychotherapy University of Muenster, Muenster, Germany
- kDepartment of Psychiatry, University of Marburg, Marburg, Germany
- lMedical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
- mSchool of Psychology, University of Queensland
- nQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
- oDivision of Psychiatry, University of Edinburgh, Edinburgh, UK
- pCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
- qControl data used in the preparation of this article were obtained from the Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium. As such, the investigators within the GERAD1 consortia contributed to the design and implementation of GERAD1 and/or provided control data but did not participate in analysis or writing of this report.
- rDiscovery Neuroscience Research, Eli Lilly and Company Ltd, Lilly Research Laboratories, Erl Wood Manor, Surrey, UK
- sDepartment of Psychiatry, University of Halle, Halle, Germany
- tDepartment of Psychiatry, University of Munich, Munich, Germany
- 1Centre for Economics of Mental and Physical Health, Health Service and Population Research Department, Institute of Psychiatry, King’s College London, London, UK.
- 2National Centre for Register-Based Research, Department of Economics and Business, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark.
- 3Centre for Integrated Register-based Research, CIRRAU, Aarhus University, Aarhus, Denmark.
- 4Toronto Western Research Institute, University Health Network, Toronto, Canada.
- 5MRC Social Genetic and Developmental Psychiatry Centre Institute of Psychiatry Psychology and Neuroscience King’s College London London UK.
- 6NIHR Biomedical Research Centre for Mental Health Maudsley Hospital and Institute of Psychiatry Psychology and Neuroscience King’s College London London UK.
- 7Department of Community Mental Health Mental Health Organization North-Holland North Heerhugowaard The Netherlands.
- 8Discovery Neuroscience Research Eli Lilly and Company Ltd Lilly Research Laboratories Erl Wood Manor Surrey UK.
- 9Department of Child & Adolescent Psychiatry Institute of Psychiatry Psychology & Neuroscience King’s College London London UK.
- 10Brighton and Sussex Medical School University of Sussex Brighton UK.
- 11University of Exeter Medical School RILD University of Exeter Exeter UK.
- 12Toxicology Unit Department of Clinical Biochemistry King’s College Hospital NHS Foundation Trust London UK.
- 13Clinical Neurosciences Studies Center Department of Psychiatry Icahn School of Medicine at Mount Sinai New York USA.
- 14Department of Genetic Epidemiology in Psychiatry Central Institute of Mental Health Medical Faculty Mannheim/Heidelberg University Mannheim Germany.
- 15Department of Psychosis Studies Institute of Psychiatry Psychology and Neuroscience King’s College London London UK.
- 16Department of Psychiatry University of Halle Halle Germany.
- 17Department of Biomedicine Aarhus University Denmark.
- 18Bioinformatics Research Centre (BiRC) Aarhus University Aarhus Denmark.
- 19Concentris Research Management GmbH Fürstenfeldbruck Germany.
- 20Leyden Delta B.V. Nijmegen The Netherlands.
- 21Department of Psychiatry Landspitali University Hospital Reykjavik Iceland.
- 22Centre for Addiction and Mental Health Toronto Ontario Canada.
- 23Psychosis Research Unit Aarhus University Hospital Risskov Denmark.
- 24MRC Centre for Neuropsychiatric Genetics and Genomics Institute of Psychological Medicine and Clinical Neurosciences School of Medicine Cardiff University Cardiff UK.
- 25Division of Psychiatry Research The Zucker Hillside Hospital Northwell Health System Glen Oaks New York USA.
- 26Department of Genomics Life & Brain Center University of Bonn Bonn Germany.
- 27Mental Health Services in the Capital Region of Denmark Mental Health Center Copenhagen University of Copenhagen Denmark.
- 28Department of Psychological Medicine Institute of Psychiatry Psychology and Neuroscience King’s College London London UK.
- 29deCODE Genetics Reykjavik Iceland.
- 30Center for Psychiatric Genomics Department of Genetics University of North Carolina Chapel Hill North Carolina USA.
- 31Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden.
- 1Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics Neurosciences and Mental Health Research Institute Department of Psychological Medicine and Neurology School of Medicine Cardiff University Cardiff UK.
- 2King’s College London Institute of Psychiatry Department of Neuroscience De Crespigny Park Denmark Hill London.
- 3Ageing Group Centre for Public Health School of Medicine Dentistry and Biomedical Sciences Queen’s University Belfast UK.
- 4Department of Psychiatry University of Bonn Sigmund-Freud-Straβe 25 53105 Bonn Germany.
- 5Institute for Molecular Psychiatry University of Bonn Bonn Germany.
- 6Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Bonn.
- 7Department of Genomics Life & Brain Center University of Bonn Bonn Germany.
- 8Departments of Psychiatry Neurology and Genetics Washington University School of Medicine St Louis MO 63110 US.
- 9Present address: Neuropsychiatric Genetics Group Department of Psychiatry Trinity Centre for Health Sciences St James’s Hospital Dublin.
- 10Present address: Department of Psychiatry University of Oxford.
- ↵*Correspondence and material requests should be addressed to M.J.O. (owenmj{at}cardiff.ac.uk), M.C.O’D. (odonovanmc{at}cardiff.ac.uk) or J.T.R.W. (waltersjt{at}cardiff.ac.uk)