ABSTRACT
Innovations in methods and technologies are equipping researchers with unprecedented capabilities for detecting and characterizing pathologic processes in the developing human brain. As a result, there is growing enthusiasm about the prospect of achieving clinically useful tools that can assist in the diagnosis and management of mental health and learning disorders. For these ambitions to be realized, it is critical to accrue large-scale multimodal datasets that capture a broad range of commonly encountered clinical psychopathology. To this end, the Child Mind Institute has launched the Healthy Brain Network (HBN), an ongoing initiative focused on creating and sharing a biobank comprised of data from 10,000 New York City area children and adolescents (ages 5-21). The HBN has adopted a community-referred recruitment model. Specifically, study advertisements seek the participation of families who have concerns about one or more psychiatric symptoms in their child. The HBN Biobank houses data about psychiatric, behavioral, cognitive, and lifestyle (e.g., fitness, diet) phenotypes, as well as multimodal brain imaging, electroencephalography, digital voice and video recordings, genetics, and actigraphy. In this paper, we present the motivation, rationale and design for the HBN along with the initial implementation and evolution of the HBN protocols. We describe the first major open data release (n = 664) containing descriptive, electroencephalography, and multimodal brain imaging data (resting state and naturalistic viewing functional MRI, diffusion MRI and morphometric MRI). Beyond accelerating transdiagnostic research, we discuss the potential of the HBN Biobank to advance related areas, such as biophysical modeling, voice and speech analysis, natural viewing fMRI and EEG, and methods optimization.
LIST OF ABBREVIATIONS
- ABCD
- Adolescent Brain Cognitive Development
- ABIDE
- Autism Brain Imaging Data Exchange
- ADHD
- Attention-Deficit/Hyperactivity Disorder
- ADOS
- Autism Diagnostic Observation Schedule
- AROMA
- Automatic Removal of Motion Artifacts
- BIA
- Bioelectrical Impedance Analysis
- CELF-5
- Clinical Evaluation of Language Fundamentals, 5th Edition
- CMI
- Child Mind Institute
- COINS
- COllaborative Informatics and Neuroimaging Suite
- CoRR
- Consortium for Reliability and Reproducibility
- CTOPP
- Comprehensive Test of Phonological Processing
- CUNY
- City University of New York
- dMRI
- diffusion magnetic resonance imaging
- DSM-5
- Diagnostic and Statistical Manual of Mental Disorders, 5th Edition
- DUA
- data usage agreement
- EEG
- electroencephalogram
- EGI
- Electrical Geodesics, Inc.
- EVT
- Expressive Vocabulary Test
- FCP
- 1000 Functional Connectomes Project
- fMRI
- functional magnetic resonance imaging
- FSIQ
- full scale intelligence quotient
- GFTA
- Goldman Fristoe Test of Articulation
- HBN
- Healthy Brain Network
- HIPPA
- Health Insurance Portability and Accountability Act
- IEP
- Individualized Education Plan
- INDI
- International Neuroimaging Data-sharing Initiative
- IQ
- intelligence quotient
- IRB
- Institutional Review Board
- KBIT
- Kaufman Brief Intelligence Test
- KSADS
- Schedule for Affective Disorders and Schizophrenia for Children
- LORIS
- Longitudinal Online Research and Imaging System
- MRI
- magnetic resonance imaging
- NIH
- National Institutes of Health
- NKI
- Nathan Kline Institute
- NY
- New York
- NYC
- New York City
- PHI
- protected health information
- PIQ
- performance intelligence quotient
- PPVT
- Peabody Picture Vocabulary Test
- QA
- quality assurance
- QAP
- quality assurance plan
- RUBIC
- Rutgers University Brain Imaging Center
- RV
- research vehicle
- SMI
- SensoMotoric Instruments
- sMRI
- structural magnetic resonance imaging
- TOWRE
- Test of Word Reading Efficiency
- VIQ
- verbal intelligence quotient
- WAIS-IV
- Wechsler Adult Intelligence Scale, 4th Edition
- WASI
- Wechsler Abbreviated Scale of Intelligence
- WIAT-III
- Wechsler Individual Achievement Test, 3rd Edition
- WISC-V
- Wechsler Intelligence Scale for Children, 5th Edition