ABSTRACT
Purpose To determine if deep learning networks could be trained to forecast a future 24-2 Humphrey Visual Field (HVF).
Design Retrospective database study.
Participants All patients who obtained a HVF 24-2 at the University of Washington.
Methods All datapoints from consecutive 24-2 HVFs from 1998 to 2018 were extracted from a University of Washington database. Ten-fold cross validation with a held out test set was used to develop the three main phases of model development: model architecture selection, dataset combination selection, and time-interval model training with transfer learning, to train a deep learning artificial neural network capable of generating a point-wise visual field prediction.
Main outcome measures Mean absolute error (MAE) and difference in Mean Deviation (MD) between predicted and actual future HVF.
Results More than 1.7 million perimetry points were extracted to the hundredth decibel from 32,443 24-2 HVFs. The best performing model with 20 million trainable parameters, CascadeNet-5, was selected. The overall MAE for the test set was 2.47 dB (95% CI: 2.45 dB to 2.48 dB). The 100 fully trained models were able to successfully predict progressive field loss in glaucomatous eyes up to 5.5 years in the future with a correlation of 0.92 between the MD of predicted and actual future HVF (p < 2.2 = 10−16) and an average difference of 0.41 dB.
Conclusions Using unfiltered real-world datasets, deep learning networks show an impressive ability to not only learn spatio-temporal HVF changes but also to generate predictions for future HVFs up to 5.5 years, given only a single HVF.
Footnotes
Conflicts of Interest: A.Y.L received hardware donation from NVIDIA Corporation. The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.