ABSTRACT
Interactions of genes in intersecting signaling pathways, as well as environmental influences, are required for the development of psoriasis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor and transcription factor which inhibits the expression of many proinflammatory genes. We tested the hypothesis that low levels of PPARγ expression promote the development of psoriatic lesions. We combined experimental results and network functional analysis to reconstruct the model of PPARγ downregulated signaling in psoriasis. We found that the expression of PPARγ maybe be slightly downregulated in human psoriatic skin and laser treatment may facilitate it. We tested the reconstructed model and found that at least on mRNA level the expression of IL17, STAT3, FOXP3, and RORC and FOSL1 genes in psoriatic skin before and after laser treatment were correlated with the level of PPARγ mRNA expression suggesting that genes belong to the same signaling pathway that may regulate the development of psoriasis lesion.
Competing Interest Statement
The authors have declared no competing interest.