User profiles for Z. Klase

Zachary Klase

Pharmacology and Physiology, Drexel College of Medicine
Verified email at drexel.edu
Cited by 3074

[HTML][HTML] Zika fetal neuropathogenesis: etiology of a viral syndrome

ZA Klase, S Khakhina, ADB Schneider… - PLoS neglected …, 2016 - journals.plos.org
… Copyright: © 2016 Klase et al. This is an open access article distributed under the terms of
… SL I and SL II were annotated from Zhu Z. et al. MBE was annotated using the UTRscan tool …

[HTML][HTML] Insights into persistent HIV-1 infection and functional cure: novel capabilities and strategies

…, J Perchik, M Freylikh, L Sardo, ZA Klase… - Frontiers in …, 2022 - frontiersin.org
Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

[HTML][HTML] MicroRNAs and HIV-1: complex interactions

Z Klase, L Houzet, KT Jeang - Journal of Biological Chemistry, 2012 - ASBMB
RNAi plays important roles in many biological processes, including cellular defense against
viral infection. Components of the RNAi machinery are widely conserved in plants and …

[HTML][HTML] HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR

Z Klase, P Kale, R Winograd, MV Gupta… - BMC molecular …, 2007 - Springer
Background RNA interference (RNAi) is a regulatory mechanism conserved in higher
eukaryotes. The RNAi pathway generates small interfering RNA (siRNA) or micro RNA (miRNA) …

[HTML][HTML] HIV-1 TAR miRNA protects against apoptosis by altering cellular gene expression

Z Klase, R Winograd, J Davis, L Carpio, R Hildreth… - Retrovirology, 2009 - Springer
Background RNA interference is a gene regulatory mechanism that employs small RNA
molecules such as microRNA. Previous work has shown that HIV-1 produces TAR viral …

[HTML][HTML] Exosomes from HIV-1-infected cells stimulate production of pro-inflammatory cytokines through trans-activating response (TAR) RNA

…, RM Hakami, MA Zadeh, B Lepene, ZA Klase… - Journal of Biological …, 2016 - ASBMB
HIV-1 infection results in a chronic illness because long-term highly active antiretroviral
therapy can lower viral titers to an undetectable level. However, discontinuation of therapy …

[HTML][HTML] Dysbiotic bacteria translocate in progressive SIV infection

Z Klase, A Ortiz, C Deleage, JC Mudd, M Quiñones… - Mucosal …, 2015 - Elsevier
Infection of gut-resident CD4 + memory T cells during acute human immunodeficiency virus (HIV)
and simian immunodeficiency virus (SIV) infection is associated with rapid loss of …

[PDF][PDF] Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells

N Calantone, F Wu, Z Klase, C Deleage, M Perkins… - Immunity, 2014 - cell.com
The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency
viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected …

Topical estrogen protects against SIV vaginal transmission without evidence of systemic effect

SM Smith, M Mefford, D Sodora, Z Klase, M Singh… - Aids, 2004 - journals.lww.com
Background: Accumulating data suggest that the state of the vaginal epithelium affects a
woman's risk of HIV vaginal transmission and several human and non-human primate studies …

[HTML][HTML] IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques

AM Ortiz, ZA Klase, SR DiNapoli, I Vujkovic-Cvijin… - Mucosal …, 2016 - Elsevier
Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been
attributed to persistent immune dysfunction, in part due to abnormalities at the gastrointestinal …