Dopamine D 2 receptor antagonism is a unifying property of all antipsychotic drugs in
clinical use. Remarkably, the effector molecules through which these medications exert their …

Dopamine D 2 receptor antagonism is a unifying property of all antipsychotic drugs in use
for schizophrenia. While often effective at ameliorating psychosis, these drugs are largely …

Antipsychotic medications are associated with major metabolic changes that contribute to
medical morbidity and a significantly shortened life span. The mechanisms for these changes …

… APA Work Group on Alzheimer's Disease and other Dementias; Peter V Rabins, Deborah
Blacker, Barry W Rovner, Teresa Rummans, Lon S Schneider, Pierre N Tariot, David M …

… 8, B and C), and they flank the Z line, as shown by counterstaining for desmin (Fig. 8, D and
E)… As expected, desmin immunoreactivity was concentrated along the Z line and absent from …

In the amyloidogenic pathway associated with Alzheimer disease ( AD ), the amyloid precursor
protein ( APP ) is cleaved by β‐secretase to generate a 99‐aa C‐terminal fragment (C99) …

… Z-series images were obtained through the depth of cells using a step size range of 0.1–0.4
μm and projected using the maximum pixel method. Deconvolution was performed with a …

Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been extensively …

Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain
uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular …

Dopamine (DA) and norepinephrine (NE) are catecholamines primarily studied in the
central nervous system that also act in the pancreas as peripheral regulators of metabolism. …