User profiles for Z. Cader

Zameel Cader

Professor of Neuroscience and Neurology, Oxford University
Verified email at ndcn.ox.ac.uk
Cited by 7684

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

…, PH Lee, C Sandor, C Webber, Z Cader… - Nature …, 2016 - nature.com
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

[PDF][PDF] GM-CSF calibrates macrophage defense and wound healing programs during intestinal infection and inflammation

…, JR Ferdinand, K Harcourt, BJ Stewart, Z Cader… - Cell reports, 2020 - cell.com
Macrophages play a central role in intestinal immunity, but inappropriate macrophage
activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-…

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

…, GD Banham, RJ Mathews, Z Cader… - Proceedings of the …, 2020 - National Acad Sciences
IgG antibodies cause inflammation and organ damage in autoimmune diseases such as
systemic lupus erythematosus (SLE). We investigated the metabolic profile of macrophages …

[HTML][HTML] Functional analysis of missense variants in the TRESK (KCNK18) K+ channel

…, LR Griffiths, GA Rouleau, GC Ebers, ZM Cader… - Scientific reports, 2012 - nature.com
A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently
been linked with typical familial migraine with aura. We now report the functional …

Mitophagy and Alzheimer's disease: cellular and molecular mechanisms

…, BA Adriaanse, NH Greig, MP Mattson, MZ Cader… - Trends in …, 2017 - cell.com
Neurons affected in Alzheimer's disease (AD) experience mitochondrial dysfunction and a
bioenergetic deficit that occurs early and promotes the disease-defining amyloid beta peptide (…

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

MZ Cader, A Kaser - Gut, 2013 - gut.bmj.com
The intestine and its immune system have evolved to meet the extraordinary task of maintaining
tolerance to the largest, most complex and diverse microbial commensal habitat, while …

Significant linkage to migraine with aura on chromosome 11q24

ZM Cader, S Noble-Topham, DA Dyment… - Human molecular …, 2003 - academic.oup.com
… The markers with scores greater than LOD=1.0 are listed in Table 1 and Figure 1 shows the
maximum LOD score ( Z max ) for each marker across the genome. The highest LOD score …

The role of ultrasound-defined tenosynovitis and synovitis in the prediction of rheumatoid arthritis development

…, L Pickup, P Nightingale, G Allen, Z Cader… - …, 2018 - academic.oup.com
Objectives Tenosynovitis (TS) is common in early arthritis. However, the value of US-defined
TS in predicting RA development is unclear. We assessed the predictive utility of US-…

Immunotherapy-responsive chorea as the presenting feature of LGI1-antibody encephalitis

…, SR Irani, BJ Cheeran, IWS Baker, ZM Cader… - Neurology, 2012 - AAN Enterprises
Cader report no disclosures. A. Vincent has received support from and/or has served as
a paid … Baker, and Z. Cader interpreted data. A. Vincent supervised the immunology and …

Habitual sleep disturbances and migraine: a Mendelian randomization study

…, PH Lee, C Sandor, C Webber, Z Cader… - Annals of clinical …, 2020 - Wiley Online Library
Z scores for heritability were all greater than 4 19 , supporting the validity of genetic … Lee
31−33 , Cynthia Sandor 71 , Caleb Webber 71 , Zameel Cader 72,73 , Bertram Muller-Myhsok 74…