Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain
uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular …

The ability of presynaptic dopamine terminals to tune neurotransmitter release to meet the
demands of neuronal activity is critical to neurotransmission. Although vesicle content has …

Parkinson’s disease is characterized by the loss of dopamine (DA) neurons in the substantia
nigra pars compacta (SNc). DA neurons in the ventral tegmental area are more resistant to …

Although long-studied in the central nervous system, there is increasing evidence that
dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin-…

Organ regeneration requires dynamic cell interactions to reestablish cell numbers and
tissue architecture. While we know the identity of progenitor cells that replace lost tissue, the …

Mitochondrial diseases produce profound neurological dysfunction via mutations affecting
mitochondrial energy production, including the relatively common Leigh syndrome (LS). We …

The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we
combine live-cell microscopy with in situ cryo–electron tomography to directly visualize ER …

Antipsychotic drugs (APD) have clinically important, adverse effects on metabolism that limit
their therapeutic utility. Pancreatic beta cells produce dopamine and express the D 2 …

In cryogenic correlated light and electron microscopy (cryo-CLEM), frozen targets of interest
are identified and located on EM grids by fluorescence microscopy and then imaged at …

Direct measurement of insulin is critical for basic and clinical studies of insulin secretion.
However, current methods are expensive and time-consuming. We developed an insulin assay …