Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or
structural alterations in ATRX and DAXX, which together encode a complex that deposits …

The chromatin template imposes an epigenetic barrier during the process of somatic cell
reprogramming. Using fibroblasts derived from macroH2A double knockout (dKO) mice, here …

Human high-grade gliomas (hHGG) remain a therapeutic challenge in neuro-oncology despite
current multimodality treatments. We recently demonstrated that murine embryonic stem …

Chromatin-mediated processes influence the development and progression of breast cancer.
Using murine mammary carcinoma-derived tumorspheres as a functional readout for an …

ATRX alterations occur at high frequency in neuroblastoma of adolescents and young adults.
Particularly intriguing are the large N-terminal deletions of ATRX (Alpha Thalassemia/…

ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability through the
regulation of repetitive sequences, such as rDNA, retrotransposons, and pericentromeric and …

Evidence has pointed to brain tumor stem cells (BTSC) as culprits behind human high-grade
glioma (hHGG) resistance to standard therapy. Pre-clinical rodent models are the mainstay …

High-grade gliomas are among the most lethal of all cancers. Despite considerable advances
in multimodality treatment, including surgery, radiotherapy and chemotherapy, the overall …

ATRX is a member of the SWI/SNF family of chromatin remodelers, originally identified as
mutated in patients with Alpha Thalassemia/Mental Retardation, X-linked syndrome. The …

The prognosis of patients with human high-grade gliomas (HGGs) remains dismal despite
major advances in their management, due mainly to the high resistance of these infiltrative …