In most tissues, the precise control of cell migration and cell-cell interaction is of paramount
importance to the development of a functional structure. Several families of secreted …

Development of neuronal circuits is controlled by evolutionarily conserved axon guidance
molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1…

Robo-Slit and Plexin-Semaphorin signaling participate in various developmental and pathogenic
processes. During commissural axon guidance in the spinal cord, chemorepulsion by …

During their migration, cerebellar granule cells switch from a tangential to a radial mode of
migration. We have previously demonstrated that this involves the transmembrane …

A minor haplotype of the 10q26 locus conveys the strongest genetic risk for age-related macular
degeneration (AMD). Here, we examined the mechanisms underlying this susceptibility. …

… Difference in gene expression (FC) is plotted on the x-axis (log2 scale), and False Discovery
Rate (FDR) adjusted significance is plotted on the y-axis (log10 scale). Genes significantly …

The development of neuronal circuits is controlled by guidance molecules that are hypothesized
to interact with the cholesterol-enriched domains of the plasma membrane termed lipid …

Netrin-1 is a secreted protein that was first identified 20 years ago as an axon guidance
molecule that regulates midline crossing in the CNS. It plays critical roles in various tissues …

Plexin-B2 deletion leads to aberrant lamination of cerebellar granule neurons (CGNs) and
Purkinje cells. Although in the cerebellum Plexin-B2 is only expressed by proliferating CGN …

Myelination is regulated by extracellular proteins, which control interactions between
oligodendrocytes and axons. Semaphorins are repulsive axon guidance molecules, which control …