User profiles for Y. Pichugin

Yuriy Pichugin

Princeton University
Verified email at princeton.edu
Cited by 286

[HTML][HTML] The evolutionary dynamics of extrachromosomal DNA in human cancers

JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie… - Nature …, 2022 - nature.com
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

[PDF][PDF] Parameters estimation in mechanism design

Y Pichugin, G Alferov, O Malafeyev - 2016 - dspace.spbu.ru
… rect measurements vector Y with a linear regression connection Y = XΘ + ε is also possible.
Pichugin, Geometrical aspects of testing the complex statistical hypothesis in mathematical …

[PDF][PDF] Statistical estimation of corruption indicators in the firm

O Malafeyev, Y Pichugin - 2016 - dspace.spbu.ru
A new statistical procedure of anti-corruption control of economic activity is proposed in the
paper. The task of the firm's corruption checking is formulated in terms of statistical …

A statistical method for corrupt agents detection

YA Pichugin, OA Malafeyev, D Rylow… - AIP Conference …, 2018 - pubs.aip.org
… Both matrices Y and N are m × J dimensional. Assume that matrices N and Y do not contain
… q, where yl is a component of the vector y with index l; the order of components is preserved. …

[HTML][HTML] Fragmentation modes and the evolution of life cycles

Y Pichugin, J Peña, PB Rainey… - PLoS computational …, 2017 - journals.plos.org
Reproduction is a defining feature of living systems. To reproduce, aggregates of biological
units (eg, multicellular organisms or colonial bacteria) must fragment into smaller parts. …

Meta‐population structure and the evolutionary transition to multicellularity

CJ Rose, K Hammerschmidt, Y Pichugin… - Ecology …, 2020 - Wiley Online Library
The evolutionary transition to multicellularity has occurred on numerous occasions, but
transitions to complex life forms are rare. Here, using experimental bacterial populations as …

Cryopreservation of rat hippocampal slices by vitrification

Y Pichugin, GM Fahy, R Morin - Cryobiology, 2006 - Elsevier
Although much interest has attended the cryopreservation of immature neurons for subsequent
therapeutic intracerebral transplantation, there are no reports on the cryopreservation of …

An environmentally induced multicellular life cycle of a unicellular cyanobacterium

S Tang, Y Pichugin, K Hammerschmidt - Current Biology, 2023 - cell.com
Understanding the evolutionary transition to multicellularity is a key problem in biology.
Nevertheless, the ecological conditions driving such transitions are not well understood. The first …

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

JT Lange, CY Chen, Y Pichugin, L Xie, J Tang… - BioRxiv, 2021 - biorxiv.org
The foundational principles of Darwinian evolution are variation, selection, and identity by
descent. Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, …

Why is cyclic dominance so rare?

HJ Park, Y Pichugin, A Traulsen - Elife, 2020 - elifesciences.org
y and z mutations happen leading the emergence of type j and k from the type n respectively.
If y … where x and y indicate the averages of the variables x and y. The index i runs over all …