Brugada syndrome
Y Mizusawa, AAM Wilde - Circulation: Arrhythmia and …, 2012 - Am Heart Assoc
A single mutation of SCN5A can lead to several phenotypes in the same family or in a single
patient, such as BrS, long-QT-syndrome type 3, sick sinus syndrome, and a variable degree …
patient, such as BrS, long-QT-syndrome type 3, sick sinus syndrome, and a variable degree …
Genetic and clinical advances in congenital long QT syndrome
Y Mizusawa, M Horie, AAM Wilde - Circulation Journal, 2014 - jstage.jst.go.jp
Congenital long QT syndrome (LQTS) is an inherited arrhythmia syndrome characterized by
a prolonged QT interval on the 12-lead ECG, torsades de pointes and a higher chance of …
a prolonged QT interval on the 12-lead ECG, torsades de pointes and a higher chance of …
Global gene expression profiling of preimplantation embryos
Preimplantation development is marked by four major events: the transition of maternal
transcripts to zygotic transcripts, compaction, the first lineage differentiation into inner cell mass …
transcripts to zygotic transcripts, compaction, the first lineage differentiation into inner cell mass …
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
CR Bezzina, J Barc, Y Mizusawa, CA Remme… - Nature …, 2013 - nature.com
… (x axis) and its association P value (left y axis). SNPs are colored according to their degree of
LD (r 2 … The tall blue spikes indicate the recombination rate (right y axis) in that region of the …
LD (r 2 … The tall blue spikes indicate the recombination rate (right y axis) in that region of the …
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na V 1.5, …
young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na V 1.5, …
[HTML][HTML] Rationale and design of the PRAETORIAN trial: a Prospective, RAndomizEd comparison of subcuTaneOus and tRansvenous ImplANtable cardioverter …
…, KM Kooiman, AH Maass, M Meine, Y Mizusawa… - American heart …, 2012 - Elsevier
… known concomitant disease with a life expectancy of <1 y … Biotronik: (in VF zone: X out of
Y, in other zones: intervals to … VF zone 25/31 NID (maximal X out of Y setting for Biotronik …
Y, in other zones: intervals to … VF zone 25/31 NID (maximal X out of Y setting for Biotronik …
Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome
N Lahrouchi, R Tadros, L Crotti, Y Mizusawa… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J …
…, T Date, Y Mizusawa, Y Kobayashi, K Satomi, Y Imai… - Europace, 2011 - academic.oup.com
Aims Atrial fibrillation (AF) is a common arrhythmia frequently associated with hypertension.
This study was designed to test the hypothesis that lowering blood pressure by angiotensin II…
This study was designed to test the hypothesis that lowering blood pressure by angiotensin II…
Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study
…, M Torchio, M Berthet, Y Mizusawa… - Cardiovascular …, 2015 - academic.oup.com
Aims Brugada syndrome (BrS) remains genetically heterogeneous and is associated with
slowed cardiac conduction. We aimed to identify genetic variation in BrS cases at loci …
slowed cardiac conduction. We aimed to identify genetic variation in BrS cases at loci …
Phenotype Variability in Patients Carrying KCNJ2 Mutations
…, J Zhou, M Kawamura, H Itoh, Y Mizusawa… - Circulation …, 2012 - Am Heart Assoc
Background— Mutations of KCNJ2, the gene encoding the human inward rectifier potassium
channel Kir2.1, cause Andersen-Tawil syndrome (ATS), a disease exhibiting ventricular …
channel Kir2.1, cause Andersen-Tawil syndrome (ATS), a disease exhibiting ventricular …