[HTML][HTML] SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19 1 .
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to allow …
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to allow …
Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells
Y Lubelsky, I Ulitsky - Nature, 2018 - nature.com
… Yoav Lubelsky and Igor Ulitsky show that the presence of a binding site for the nuclear
protein HNRNPK in lncRNAs can promote the nuclear accumulation of these RNA molecules in …
protein HNRNPK in lncRNAs can promote the nuclear accumulation of these RNA molecules in …
[HTML][HTML] A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells
A Tichon, N Gil, Y Lubelsky, T Havkin Solomon… - Nature …, 2016 - nature.com
Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome,
and hundreds of them are evolutionarily conserved, but their functions and modes of action …
and hundreds of them are evolutionarily conserved, but their functions and modes of action …
Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly
JA Belsky, HK MacAlpine, Y Lubelsky… - Genes & …, 2015 - genesdev.cshlp.org
… Recovered and sequenced MNase fragments are displayed with their chromosomal coordinate
on the X-axis and their fragment length on the Y-axis. Clusters of reads in the ∼150- to …
on the X-axis and their fragment length on the Y-axis. Clusters of reads in the ∼150- to …
DNA replication and transcription programs respond to the same chromatin cues
Y Lubelsky, JA Prinz, L DeNapoli, Y Li… - Genome …, 2014 - genome.cshlp.org
DNA replication is a dynamic process that occurs in a temporal order along each of the
chromosomes. A consequence of the temporally coordinated activation of replication origins is …
chromosomes. A consequence of the temporally coordinated activation of replication origins is …
[HTML][HTML] A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes
…, R Ben-Tov Perry, Z Meir, G Housman, Y Lubelsky… - Genome biology, 2017 - Springer
… species) and Y (in human or mouse) such that (i) X and Y are … size) to a GLCP; (iii) Y is the
flanking gene within a certain … of the GLCP to X and the lncRNA to Y is the same. In the second …
flanking gene within a certain … of the GLCP to X and the lncRNA to Y is the same. In the second …
Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone
Y Lubelsky, T Sasaki, MA Kuipers, I Lucas… - Nucleic acids …, 2011 - academic.oup.com
Genome-scale mapping of pre-replication complex proteins has not been reported in
mammalian cells. Poor enrichment of these proteins at specific sites may be due to dispersed …
mammalian cells. Poor enrichment of these proteins at specific sites may be due to dispersed …
Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest
The yeast Saccharomyces cerevisiae Crt1 transcription repressor is an effector of the DNA
damage and replication checkpoint pathway. Crt1 binds and represses genes encoding …
damage and replication checkpoint pathway. Crt1 binds and represses genes encoding …
[HTML][HTML] Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage
N Degani, Y Lubelsky, RBT Perry, E Ainbinder… - PLoS …, 2021 - journals.plos.org
Long noncoding RNAs (lncRNAs) have been shown to play important roles in gene regulatory
networks acting in early development. There has been rapid turnover of lncRNA loci …
networks acting in early development. There has been rapid turnover of lncRNA loci …
High‐resolution mapping of function and protein binding in an RNA nuclear enrichment sequence
Y Lubelsky, B Zuckerman, I Ulitsky - The EMBO journal, 2021 - embopress.org
… Boxplots compare the difference between the values on the y-axis and the x-axis for
sequences with the indicated number of X → C mutations. Ratios are based on two replicates for …
sequences with the indicated number of X → C mutations. Ratios are based on two replicates for …