[HTML][HTML] SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

…, R Winkler, T Fisher, B Rozman, O Mizrahi, Y Lubelsky… - Nature, 2021 - nature.com
The coronavirus SARS-CoV-2 is the cause of the ongoing pandemic of COVID-19 1 .
Coronaviruses have developed a variety of mechanisms to repress host mRNA translation to allow …

Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells

Y Lubelsky, I Ulitsky - Nature, 2018 - nature.com
… Yoav Lubelsky and Igor Ulitsky show that the presence of a binding site for the nuclear
protein HNRNPK in lncRNAs can promote the nuclear accumulation of these RNA molecules in …

[HTML][HTML] A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

A Tichon, N Gil, Y Lubelsky, T Havkin Solomon… - Nature …, 2016 - nature.com
Thousands of long noncoding RNA (lncRNA) genes are encoded in the human genome,
and hundreds of them are evolutionarily conserved, but their functions and modes of action …

Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly

JA Belsky, HK MacAlpine, Y Lubelsky… - Genes & …, 2015 - genesdev.cshlp.org
… Recovered and sequenced MNase fragments are displayed with their chromosomal coordinate
on the X-axis and their fragment length on the Y-axis. Clusters of reads in the ∼150- to …

DNA replication and transcription programs respond to the same chromatin cues

Y Lubelsky, JA Prinz, L DeNapoli, Y Li… - Genome …, 2014 - genome.cshlp.org
DNA replication is a dynamic process that occurs in a temporal order along each of the
chromosomes. A consequence of the temporally coordinated activation of replication origins is …

[HTML][HTML] A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes

…, R Ben-Tov Perry, Z Meir, G Housman, Y Lubelsky… - Genome biology, 2017 - Springer
… species) and Y (in human or mouse) such that (i) X and Y are … size) to a GLCP; (iii) Y is the
flanking gene within a certain … of the GLCP to X and the lncRNA to Y is the same. In the second …

Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone

Y Lubelsky, T Sasaki, MA Kuipers, I Lucas… - Nucleic acids …, 2011 - academic.oup.com
Genome-scale mapping of pre-replication complex proteins has not been reported in
mammalian cells. Poor enrichment of these proteins at specific sites may be due to dispersed …

Autorepression of rfx1 gene expression: functional conservation from yeast to humans in response to DNA replication arrest

Y Lubelsky, N Reuven, Y Shaul - Molecular and cellular biology, 2005 - Taylor & Francis
The yeast Saccharomyces cerevisiae Crt1 transcription repressor is an effector of the DNA
damage and replication checkpoint pathway. Crt1 binds and represses genes encoding …

[HTML][HTML] Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage

N Degani, Y Lubelsky, RBT Perry, E Ainbinder… - PLoS …, 2021 - journals.plos.org
Long noncoding RNAs (lncRNAs) have been shown to play important roles in gene regulatory
networks acting in early development. There has been rapid turnover of lncRNA loci …

High‐resolution mapping of function and protein binding in an RNA nuclear enrichment sequence

Y Lubelsky, B Zuckerman, I Ulitsky - The EMBO journal, 2021 - embopress.org
… Boxplots compare the difference between the values on the y-axis and the x-axis for
sequences with the indicated number of X → C mutations. Ratios are based on two replicates for …