… Hasegawa, M.; Morishima-Kawashima, M.; Takio, K.; Suzuki, M.; Titani, K.; Ihara, Y. Protein
sequence … Yoshida, H.; Ihara, Y. r in paired helical filaments is functionally distinct from fetal-r: …

… We (Hiroshi Mori and Yasuo Ihara) employed a two-step screening procedure to identify
monoclonals in the resultant hybridoma supernatants: first by enzyme-linked immunosorbent …

Research on the molecular pathogenesis of Alzheimer's disease (AD) has made great
strides over the last decade. This progress is the result of protein chemical analysis of two …

We present Advanced Camera for Surveys, NICMOS, and Keck adaptive-optics-assisted
photometry of 20 Type Ia supernovae (SNe Ia) from the Hubble Space Telescope (HST) Cluster …

… filaments (PHF), the X and Y peptides might have derived from potentially contaminating
PHF. To exclude this possibility, we set out to localize X and Y with immunological probes. …

To learn about the carboxy-terminal extent of amyloid g-protein (Ag) composition of senile
plaques (SPs) in the brain affected with Alzheimer’s disease (AD), we employed two end-…

Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by
absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP. …

We have purified and characterized the growth inhibitory factor (GIF) that is abundant in the
normal human brain, but greatly reduced in the Alzheimer’s disease (AD) brain. CIF inhibited …

Paired helical filaments (PHF), which constitute a distinct type of pathological neuronal fiber,
are the principal constituent of neurofibrillary tangles that occur in the brain of patients with …

Amyloid β protein (Aβ), a pathogenic molecule associated with Alzheimer's disease, is
produced by γ-secretase, which cleaves the β-carboxyl terminal fragment (βCTF) of β-amyloid …