The innate immune defense system involves the activity of endogenous antimicrobial peptides
(AMPs), which inhibit the growth of most microbes. In insects, genes encoding AMPs are …

… from immunoresponsive cells and tissues (Roos E, Björklund G, Engström Y. unpublished).
It is therefore likely that Cactus can act as a cytoplasmic inhibitor of both Dorsal and Dif. …

… 19 Onfelt Tingvall T, Roos E, Engstrom Y: The imd gene is required for local cecropin expression
in Drosophila barrier epithelia. EMBO Rep 2001; 2: 239–243. 20 Wagner C, Isermann K…

There are striking parallels between the regulation of gene expression along the dorsoventral
(DV) axis of Drosophila embryos and lymphoid-restricted expression in the mammalian …

Consistent with its specialized role in DNA synthesis, the activity of ribonucleotide reductase
is cell cycle-dependent, reaching its maximum during S-phase. This paper demonstrates, …

The Rel/NF‐κB transcription factor Relish plays a key role in the humoral immune response
in Drosophila. We now find that activation of this innate immune response is preceded by …

The NF-κB-like transcription factor Relish plays a central role in the innate immune response
of Drosophila. Unlike other NF-κB proteins, Relish is activated by endoproteolytic cleavage …

Jun N‐terminal kinase (JNK) signaling is a highly conserved pathway that controls both
cytoskeletal remodeling and transcriptional regulation in response to a wide variety of signals. …

The mammalian transcription factor NF-κB regulates a number of genes involved in immune
and acute phase responses, by interacting with a nucleotide sequence element, the κB-motif…

The Toll gene encodes an interleukin 1 receptor-like protein that mediates dorsoventral
polarity in the Drosophila embryo. The possible involvement of Toll or Toll-like proteins also in …