Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal
circumstances interacts with ligand at the cell surface and mediates various essential roles in a …

Growth factors (GFs) hold considerable promise for disease modification in neurodegenerative
disorders because they can protect and restore degenerating neurons and also enhance …

Glial cell line–derived neurotrophic factor (GDNF) family ligands (GFLs) are potent survival
factors for dopaminergic neurons and motoneurons with therapeutic potential for Parkinson’s …

Rearranged during transfection (RET), in complex with glial cell line-derived (GDNF) family
receptor alpha (GFRα), is the canonical signaling receptor for GDNF family ligands (GFLs) …

Glial cell line-derived neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor
GDNF family receptor α1 (GFRα1) in a 2:2 ratio and signals through the receptor …

Neuropathic pain caused by nerve damage is a common and severe class of chronic pain.
Disease-modifying clinical therapies are needed as current treatments typically provide only …

Well-known effects of neurotrophic factors are related to supporting the survival and functioning
of various neuronal populations in the body. However, these proteins seem to also play …

Background Motor symptoms of Parkinson's disease (PD) are caused by degeneration and
progressive loss of nigrostriatal dopamine neurons. Currently, no cure for this disease is …

Neurotrophic factors promote survival, proliferation and differentiation of neurons inducing
intracellular signaling via specific receptors. The conventional biochemical methods often fail …

Background: Parkinson's disease (PD) is the second most common neurodegenerative
disorder worldwide, the lifetime risk of developing this disease is 1.5%. Motor diagnostic …