Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand
1 (PD-L1) pathway can induce robust and durable responses in patients with various …

… Coefficients are plotted on the y-axis in bar plots and asterisks are added to indicate level
of significance, as denoted in the legend. Tumor types are ordered in the same order as in Fig. …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade. …

10.7554/eLife.10769.001 Mutations, deletions, and changes in copy number of mitochondrial
DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number …

On the basis of multidimensional and comprehensive molecular characterization (including
DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal …

As tumors accumulate genetic alterations, an evolutionary process occurs in which
genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic …

Myeloid cells encounter stromal cells and their matrix determinants on a continual basis
during their residence in any given organ. Here, we examined the impact of the collagen …

Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy.
Understanding tumor-intrinsic determinants of immunotherapy resistance is critical to improve …

Protein expression and post-translational modification levels are tightly regulated in
neoplastic cells to maintain cellular processes known as ‘cancer hallmarks’. The first Pan-Cancer …

The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated
with poor clinical outcomes in cancer patients and thus represents a promising therapeutic …