We present an integrated approach to identify genetic mechanisms that control self-renewal
in mouse embryonic stem cells. We use short hairpin RNA (shRNA) loss-of-function …

Metabolic reprogramming is critical to oncogenesis, but the emergence and function of this
profound reorganization remain poorly understood. Here we find that cooperating oncogenic …

2-Hydroxyglutarate (2-HG) is an important epigenetic regulator, with potential roles in cancer
and stem cell biology. The d-(R)-enantiomer (d-2-HG) is an oncometabolite generated from …

We have previously reported that human cytomegalovirus (HCMV) infection induces large-scale
changes to host cell glycolytic, nucleic acid, and phospholipid metabolism. Here we …

Viruses depend on the host cell to provide the energy and biomolecular subunits necessary
for production of viral progeny. We have previously reported that human cytomegalovirus (…

Viral infection frequently triggers activation of host innate immune pathways that attempt to
limit viral spread. The NF-κB pathway is a critical component that governs this response. We …

Human Cytomegalovirus (HCMV) infection induces several metabolic activities that are
essential for viral replication. Despite the important role that this metabolic modulation plays …

Two-dimensional patterning of the follicular epithelium in Drosophila oogenesis is required
for the formation of three-dimensional eggshell structures. Our analysis of a large number of …

Ischemic preconditioning (IPC) protects tissues such as the heart from prolonged ischemia-reperfusion
(IR) injury. We previously showed that the lysine deacetylase SIRT1 is required …

Viruses depend on cellular metabolic resources to supply the energy and biomolecular building
blocks necessary for their replication. Human cytomegalovirus (HCMV), a leading cause …