User profiles for X. Gidrol

Xavier GIDROL

Directeur de Laboratoire CEA Grenoble
Verified email at cea.fr
Cited by 6162

Cell microarrays in drug discovery

D Castel, A Pitaval, MA Debily, X Gidrol - Drug discovery today, 2006 - Elsevier
… To date, two major types of cell microarrays have been described: positional cell microarrays,
in which cells are arranged on a surface and given x and y coordinates, and batch or …

A 3D toolbox to enhance physiological relevance of human tissue models

…, L Liguori, C Marquette, S Le Gac, X Gidrol… - Trends in …, 2016 - cell.com
We discuss the current challenges and future prospects of flow-based organoid models and
3D self-assembling scaffolds. The existing paradigm of 3D culture suffers from a lack of …

[HTML][HTML] CRISPR-Cas9 technology for the creation of biological avatars capable of modeling and treating pathologies: From discovery to the latest improvements

A Nasrallah, E Sulpice, F Kobaisi, X Gidrol, W Rachidi - Cells, 2022 - mdpi.com
… Hashikawa and his team also succeeded in generating a stable strain of rabbits with X-linked
severe combined immunodeficiency (X-SCID), harboring a phenotype that encompasses …

Cardiac glycosides exert anticancer effects by inducing immunogenic cell death

…, F Schlemmer, E Sulpice, C Locher, X Gidrol… - Science translational …, 2012 - science.org
Some successful chemotherapeutics, notably anthracyclines and oxaliplatin, induce a type
of cell stress and death that is immunogenic, hence converting the patient’s dying cancer …

Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is involved in the coagulation of latex.

X Gidrol, H Chrestin, HL Tan, A Kush - Journal of Biological Chemistry, 1994 - ASBMB
Hevein, a lectin-like protein is the major protein of vacuolar structures called lutoids in the
latex of rubber trees. We have shown both by in planta and ex planta studies that hevein is …

[HTML][HTML] Pre-microRNA and mature microRNA in human mitochondria

…, B Bonnamy, D Damas, O Boyer, X Gidrol - PloS one, 2011 - journals.plos.org
Background Because of the central functions of the mitochondria in providing metabolic
energy and initiating apoptosis on one hand and the role that microRNA (miRNA) play in gene …

[HTML][HTML] Genome-wide location of yeast RNA polymerase III transcription machinery

O Harismendy, CG Gendrel, P Soularue, X Gidrol… - The EMBO …, 2003 - embopress.org
RNA polymerase III (Pol III) transcribes a large set of genes encoding small untranslated
RNAs like tRNAs, 5S rRNA, U6 snRNA or RPR1 RNA. To get a global view of class III (Pol III-…

An EWOD-based microfluidic chip for single-cell isolation, mRNA purification and subsequent multiplex qPCR

…, Y Fouillet, G Castellan, A Bellemin-Comte, X Gidrol - Lab on a Chip, 2014 - pubs.rsc.org
Single cell analysis circumvents the need to average data from large populations by observing
each cell individually, thus enabling the analysis of cell-to-cell variability. The ability to …

Accumulation of reactive oxygen species and oxidation of cytokinin in germinating soybean seeds

X Gidrol, WS Lin, N Dégousée, SF Yip… - European Journal of …, 1994 - Wiley Online Library
Seed germination is an important developmental switch when quiescent seed cells initiate
oxidative phosphorylation for further development and differentiation. During early imbibition …

[HTML][HTML] High-content monitoring of drug effects in a 3D spheroid model

F Mittler, P Obeïd, AV Rulina, V Haguet, X Gidrol… - Frontiers in …, 2017 - frontiersin.org
A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …