Despite the fact that more than 5000 safety-related studies have been published on bisphenol
A (BPA), there seems to be no resolution of the apparently deadlocked controversy as to …

During the last two decades, substantial efforts have been made towards the development
and international acceptance of alternative methods to safety studies using laboratory animals…

Nanotechnology offers enormous potential for technological progress. Fortunately, early and
intensive efforts have been invested in investigating toxicology and safety aspects of this …

Background Safety assessment for repeated dose toxicity is one of the largest challenges in
the process to replace animal testing. This is also one of the proof of concept ambitions of …

Currently, comprehensive toxicological data are available only for a small percentage of the
30,000 substances produced in volumes of 1–100 tons per year in the EU. Substances with …

… The enzyme was eluted by a linear decreasing gradient from 45 to 20 % (w/v) ammonium
sulfate. Enzyme-containing fractions were desalted by gel filtration on a Sephadex G-25 …

(1) The role of conjugating enzymes is best understood by looking at the interaction
between phase I (mostly cytochromes P-450) and phase II (conjugation) enzymes of drug …

… The mucosa was scraped off with a spatula and homogenates (20%, w/v) were prepared in
… An initial dose of 100 mgikg was given once ip and was followed by 0.1% (w/v) in drinking …

The selectivity of various inducers of UDP-glucuronosyltransferase was investigated in rat
liver microsomes and compared with their effect on monooxygenase reactions. (1) Similar to 3-…

… W. Reutter. Details about the tumors are given by Harms et al. … Addition of UDP-W-acetylglucosamine,
probably a physiological activator of the enzyme (42), led to 2fold activation with …