Variation in gene expression is an important mechanism underlying susceptibility to complex
disease. The simultaneous genome-wide assay of gene expression and genetic variation …

The diseases of asthma, eczema and hay fever are typified by reactions to common allergens,
which are mediated by immunoglobulin E. These allergic diseases are increasing in …

… Cookson, W. Genetics and genomics of asthma and allergic diseases. Immunol. … Bowcock,
AM & Cookson, WO The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum. …

Background The study of microbial communities has been revolutionised in recent years by
the widespread adoption of culture independent analytical techniques such as 16S rRNA …

… , with elements T θa,b (v,w)=θ a,b r(v,w) (1−θ a,b ) 2n−r(v,w) , where r(v,w) is the number of
differences between inheritance vectors v and w. Then left conditional likelihoods at locus c, λ …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in …

Asthma is caused by a combination of poorly understood genetic and environmental factors
1 , 2 . We have systematically mapped the effects of single nucleotide polymorphisms (SNPs…

Background A rich microbial environment in infancy protects against asthma [1] , [2] and
infections precipitate asthma exacerbations [3] . We compared the airway microbiota at three …

Background Children who grow up in environments that afford them a wide range of microbial
exposures, such as traditional farms, are protected from childhood asthma and atopy. In …

High-resolution mapping is an important step in the identification of complex disease genes.
In outbred populations, linkage disequilibrium is expected to operate over short distances …