Lung cancer cell lines have made a substantial contribution to lung cancer translational
research and biomedical discovery. A systematic approach to initiating and characterizing cell …

Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors,
including smoking and exposure to environmental carcinogens, have been linked to …

The rise of Japan from agrarianism to a position as one of the leading industrial powers is
one of the most dramatic and meaningful phenomena in economic history. Professor …

Array comparative genomic hybridization (array CGH) is a method used to detect segmental
DNA copy number alterations. Recently, advances in this technology have enabled high-…

We investigated the frequency and function of mutations and increased copy number of the
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes …

Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling
factors that associate with acetylated histones and facilitate transcription of target genes. …

Background Activating mutations in one allele of an oncogene (heterozygous mutations)
are widely believed to be sufficient for tumorigenesis. However, mutant allele specific …

The RAS family of proto-oncogenes are among the most commonly mutated genes in human
cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic …

Background Deregulation of EGFR signaling is common in non-small cell lung cancers (NSCLC)
and this finding led to the development of tyrosine kinase inhibitors (TKIs) that are …

… Lockwood and R. Chari were supported by a doctoral research award from the Natural
Sciences and Engineering Research Council of Canada, CIHR, and MSFHR. A. …