User profiles for W. R. Heath
William HeathDepartment of Microbiology and Immunology, University of Melbourne Verified email at unimelb.edu.au Cited by 49945 |
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
Cross‐presentation involves the uptake and processing of exogenous antigens within the
major histocompatibility complex (MHC) class I pathway. This process is primarily performed …
major histocompatibility complex (MHC) class I pathway. This process is primarily performed …
Cross-presentation, dendritic cells, tolerance and immunity
WR Heath, FR Carbone - Annual review of immunology, 2001 - annualreviews.org
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a)
the antigenic requirements for cross-presentation, (b) the phenotype of the antigen …
the antigenic requirements for cross-presentation, (b) the phenotype of the antigen …
Memory T cell subsets, migration patterns, and tissue residence
…, T Gebhardt, FR Carbone, WR Heath - Annual review of …, 2013 - annualreviews.org
… on dermal fibroblasts in the skin (SN Mueller & WR Heath, unpublished observations). …
Gebhardt, FR Carbone & WR Heath, unpublished observations). These findings are consistent …
Gebhardt, FR Carbone & WR Heath, unpublished observations). These findings are consistent …
T cell receptor antagonist peptides induce positive selection
We have used organ culture of fetal thymic lobes from T cell receptor (TCR) transgenic j? &f (-I-)
mice to study the role of peptides in positive selection. The TCR used was from a CD8+ …
mice to study the role of peptides in positive selection. The TCR used was from a CD8+ …
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
…, F Karamalis, RA Flavell, JFAP Miller, WR Heath - Nature, 1998 - nature.com
Cytotoxic T lymphocytes (CTLs) which carry the CD8 antigen recognize antigens that are
presented on target cells by the class I major histocompatibility complex. CTLs are responsible …
presented on target cells by the class I major histocompatibility complex. CTLs are responsible …
Defective TCR expression in transgenic mice constructed using cDNA‐based α‐and β‐chain genes under the control of heterologous regulatory elements
MJ Barnden, J Allison, WR Heath… - Immunology and cell …, 1998 - Wiley Online Library
We describe the generation of ovalbumin (OVA)‐specific, MHC class II‐restricted αβ T cell
receptor (TCR) transgenic mice. Initial attempts at generating these transgenic mice utilized …
receptor (TCR) transgenic mice. Initial attempts at generating these transgenic mice utilized …
[HTML][HTML] Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
Effective immunity is dependent on long-surviving memory T cells. Various memory subsets
make distinct contributions to immune protection, especially in peripheral infection. It has …
make distinct contributions to immune protection, especially in peripheral infection. It has …
The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
…, T Stefanovic, DC Tscharke, WR Heath… - Nature …, 2013 - nature.com
Tissue-resident memory T cells (T RM cells) provide superior protection against infection in
extralymphoid tissues. Here we found that CD103 + CD8 + T RM cells developed in the skin …
extralymphoid tissues. Here we found that CD103 + CD8 + T RM cells developed in the skin …
Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help
…, F Karamalis, JFAP Miller, WR Heath - The Journal of …, 1997 - rupress.org
Class I–restricted presentation is usually associated with cytoplasmic degradation of cellular
proteins and is often considered inaccessible to exogenous antigens. Nonetheless, certain …
proteins and is often considered inaccessible to exogenous antigens. Nonetheless, certain …
Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells
…, FR Carbone, JFAP Miller, WR Heath - The Journal of …, 1997 - rupress.org
In this report, we show that cross-presentation of self-antigens can lead to the peripheral
deletion of autoreactive CD8 + T cells. We had previously shown that transfer of ovalbumin (OVA…
deletion of autoreactive CD8 + T cells. We had previously shown that transfer of ovalbumin (OVA…