MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …

Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on
a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this …

In the past several years, single-molecule sequencing platforms, such as those by Pacific
Biosciences and Oxford Nanopore Technologies, have become available to researchers and …

MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can
regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by …

MicroRNAs (miRNAs) are 20–23 nucleotide (nt) RNA molecules that regulate gene expression
post-transcriptionally. A key step toward understanding the function of the hundreds of …

Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as
muscle differentiation, synapse function, and insulin secretion. In addition, analysis of Dicer …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Experimental
in vitro models that faithfully capture the hallmarks and tumor heterogeneity of OC are …

Background MicroRNA (miRNA) encoding genes are abundant in vertebrate genomes but
very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA …

Mutations create variation in the population, fuel evolution and cause genetic diseases. Current
knowledge about de novo mutations is incomplete and mostly indirect 1 , 2 , 3 , 4 , 5 , 6 , …

Despite improvements in genomics technology, the detection of structural variants (SVs) from
short-read sequencing still poses challenges, particularly for complex variation. Here we …