User profiles for W. P. Hanage

William Hanage

Harvard TH Chan School of Public Health
Verified email at hsph.harvard.edu
Cited by 31227

Horizontal gene transfer and adaptive evolution in bacteria

BJ Arnold, IT Huang, WP Hanage - Nature Reviews Microbiology, 2022 - nature.com
Horizontal gene transfer (HGT) is arguably the most conspicuous feature of bacterial evolution.
Evidence for HGT is found in most bacterial genomes. Although HGT can considerably …

[HTML][HTML] Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications

AT Levin, WP Hanage, N Owusu-Boaitey… - European journal of …, 2020 - Springer
Determine age-specific infection fatality rates for COVID-19 to inform public health policies
and communications that help protect vulnerable age groups. Studies of COVID-19 …

Antibiotics in agriculture and the risk to human health: how worried should we be?

…, M Lipsitch, WP Hanage - Evolutionary …, 2015 - Wiley Online Library
The use of antibiotics in agriculture is routinely described as a major contributor to the clinical
problem of resistant disease in human medicine. While a link is plausible, there are no …

The effect of human mobility and control measures on the COVID-19 epidemic in China

…, L Du Plessis, NR Faria, R Li, WP Hanage… - Science, 2020 - science.org
The ongoing coronavirus disease 2019 (COVID-19) outbreak expanded rapidly throughout
China. Major behavioral, clinical, and state interventions were undertaken to mitigate the …

Pandemic potential of a strain of influenza A (H1N1): early findings

C Fraser, CA Donnelly, S Cauchemez, WP Hanage… - science, 2009 - science.org
A novel influenza A (H1N1) virus has spread rapidly across the globe. Judging its pandemic
potential is difficult with limited data, but nevertheless essential to inform appropriate health …

eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data

EJ Feil, BC Li, DM Aanensen, WP Hanage… - Journal of …, 2004 - Am Soc Microbiol
The introduction of multilocus sequence typing (MLST) for the precise characterization of
isolates of bacterial pathogens has had a marked impact on both routine epidemiological …

[HTML][HTML] Persistence and evolution of SARS-CoV-2 in an immunocompromised host

…, G Alter, AK Barczak, WP Hanage… - … England Journal of …, 2020 - Mass Medical Soc
SARS-CoV-2 in an Immunocompromised Host This letter describes an immunocompromised
patient who had persistent infection with SARS-CoV-2 over a period of months, despite …

Rapid pneumococcal evolution in response to clinical interventions

…, A Tomasz, KP Klugman, J Parkhill, WP Hanage… - science, 2011 - science.org
Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus
pneumoniae have previously been confounded by high rates of recombination. Sequencing …

[HTML][HTML] An omics-based framework for assessing the health risk of antimicrobial resistance genes

…, E Topp, MR Gillings, WP Hanage… - Nature …, 2021 - nature.com
Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs
pose serious threats to public health, highlighting the importance of identifying those that are …

Recombination and the nature of bacterial speciation

C Fraser, WP Hanage, BG Spratt - Science, 2007 - science.org
Genetic surveys reveal the diversity of bacteria and lead to the questioning of species concepts
used to categorize bacteria. One difficulty in defining bacterial species arises from the …