Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

… I am grateful to members of the Hancock lab, particularly Keith Mickolajczyk, Geng-Yuan (Scott)
Chen, and Shankar Shastry, and my collaborators in the Block lab, Johan Andreasson …

… Hancock* Department of Biomedical Engineering, Pennsylvania State University, University
Park, … The authors also thank the Hancock lab for helpful suggestions and the M4 gang for …

MCAK belongs to the Kin I subfamily of kinesin-related proteins, a unique group of motor
proteins that are not motile but instead destabilize microtubules. We show that MCAK is an …

When not bound to cargo, the motor protein kinesin is in an inhibited state that has low
microtubule-stimulated ATPase activity. Inhibition serves to minimize the dissipation of ATP and to …

A single kinesin molecule can move for hundreds of steps along a microtubule without
dissociating. One hypothesis to account for this processive movement is that the binding of …

Kinesin is a processive motor protein: A single molecule can walk continuously along a
microtubule for several micrometers, taking hundreds of 8-nm steps without dissociating. To …

… Shastry S, Hancock WO. 2010. Neck linker length determines the degree of processivity in
… Shastry S, Hancock WO. 2011. Interhead tension determines processivity across diverse N-…

Kinesin-1 is a dimeric motor protein, central to intracellular transport, that steps hand-over-hand
toward the microtubule (MT) plus-end, hydrolyzing one ATP molecule per step. Its …

Defining the mechanical and biochemical determinates of kinesin processivity is important
for understanding how diverse kinesins are tuned for specific cellular functions. Because …