Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines
in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-…

INTRODUCTION Loss-of-function mutations in one gene copy can lead to reduced amounts
of protein and, consequently, human disease, a condition termed haploinsufficiency. It is …

The vertebral column derives from somites, which are transient paired segments of
mesoderm that surround the neural tube in the early embryo. Somites are formed by a genetic …

Pathogenic COPA variants cause a Mendelian syndrome of immune dysregulation with
elevated type I interferon signaling. COPA is a subunit of coat protein complex I (COPI) that …

Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong
female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals…

Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a
functional tail. Understanding the molecular basis of this process would advance regenerative …

Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide.
There are significant racial/ethnic differences in albuterol drug response. Objectives: To …

Standard cell culture guidelines often use media supplemented with antibiotics to prevent
cell contamination. However, relatively little is known about the effect of antibiotic use in cell …

Inguinal hernia repair is one of the most commonly performed operations in the world, yet
little is known about the genetic mechanisms that predispose individuals to develop inguinal …

This paper introduces a novel treatment function into an SIR model with bi-linear infection
force. Treatment is assumed to increase at a decreasing rate as the sub-population of infected …