Clonal populations of microbial cells often show a high degree of phenotypic variability
under homogeneous conditions. Stochastic fluctuations in the cellular components that …

Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

… Wiep Klaas Smits … Smits and co-workers 10 based their argument that ComK
autostimulation is responsible for bistability on two lines of research (Fig. 2b). First, a strain of B. …

In Bacillus subtilis competence for genetic transformation develops only in a subpopulation
of cells in an isogenic culture. The molecular mechanisms underlying this phenotypic …

… We experienced that inoculation of overnight cultures with colonies from plate (no older
than a week), instead of inoculation from frozen stocks, resulted in better development of …

Background Clostridium difficile is an anaerobic, Gram-positive bacterium that can reside as
a commensal within the intestinal microbiota of healthy individuals or cause life-threatening …

Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in
NOTCH1 or FBXW7 is a frequent phenomenon in T-cell acute lymphoblastic leukemia (T-ALL). …

Background PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia,
but their overall impact and associations with other genetic aberrations is unknown. PTEN …

The rok gene of Bacillus subtilis was identified as a negative regulator of competence
development. It also controls expression of several genes not related to competence. We found …

Background Pediatric acute lymphoblastic leukemia (ALL) is the most common childhood
cancer and the leading cause of cancer-related mortality in children. T cell ALL (T-ALL) …