… We have recently demonstrated that TgIF2K-D enhances the survival of extracellular
tachyzoites deprived of host cell resources (Sullivan, unpublished data). The roles of the other …

A critical factor in the transmission and pathogenesis of Toxoplasma gondii is the ability to
convert from an acute disease-causing, proliferative stage (tachyzoite), to a chronic, dormant …

The life cycles of apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii
are complex, consisting of proliferative and latent stages within multiple hosts. Dramatic …

The tetracycline antibiotics are widely used in biomedical research as mediators of inducible
gene expression systems. Despite many known effects of tetracyclines on mammalian cells…

… WJ Sullivan is supported by an R01 grant from the National Institutes of Health (GM065051).
N. … Bhatti, MM, and WJ Sullivan, Jr. Histone acetylase GCN5 enters the nucleus via importin-…

The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability
and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as …

Parasitic protozoal infections have long been known to cause profound degrees of sickness
and death in humans as well as animal populations. Despite the increase in the number of …

Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying
cause of chronic toxoplasmosis. Consequently, mechanisms responsible for controlling …

Sporozoites, the invasive form of malaria parasites transmitted by mosquitoes, are quiescent
while in the insect salivary glands. Sporozoites only differentiate inside of the hepatocytes …

A key problem in the treatment of numerous pathogenic eukaryotes centers on their
development into latent forms during stress. For example, the opportunistic protist Toxoplasma …