The uric-6 gene is required for the guidance of pioneer axons and migrating cells along the
body wall in C. elegans. In mutants, dorsal and ventral migrations are disrupted, but …

Netrins are laminin-related proteins that guide circumferential migrations on the ectoderm.
To understand how netrin cues direct cell movements, we examined the expression of …

Abstract Changes in energy metabolism during larval development in Caenorhabditis elegans
have been investigated using phosphorus nuclear magnetic resonance ( 31 P NMR). The …

Laminins are heterotrimeric (α/β/γ) glycoproteins that form a major polymer within basement
membranes. Different α, β andγ subunits can assemble into various laminin isoforms that …

Vertebrate laminins and netrins share N-terminal domain structure, but appear to be only
distantly related. Both families can be divided into different subfamilies on the basis of structural …

Basement membranes can help determine pathways of migrating axons. Although members
of the nidogen (entactin) protein family are structural components of basement membranes, …

The correct wiring of neuronal circuits depends on outgrowth and guidance of neuronal
processes during development. In the past two decades, great progress has been made in …

Caenorhabditis elegans requires sterol, usually supplied as cholesterol, but this is enzymatically
modified, and different sterols can substitute. Sterol deprivation decreased brood size …

… We thank Peter Yurchenco and Martha Soto for helpful discussions; Xing-Cong Ren and
other members of the Wadsworth Laboratory for assistance with strain constructions; the …

Background Axon migrations are guided by extracellular cues that can act as repellants or
attractants. However, the logic underlying the manner through which attractive and repulsive …