… 18, WC Hahn and RA Weinberg, unpublished observations) pre-senescent primary
human cells to multiply indefinitely. Moreover, ectopic hTERT enzyme expression enables …

Cancer arises from a stepwise accumulation of genetic changes that liberates neoplastic cells
from the homeostatic mechanisms that govern normal cell proliferation. In humans, at least …

MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to
modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have …

… Wei and members of the Hahn laboratory for discussions. High-throughput RNAi
screening was conducted at the RNAi Platform of the Broad Institute of MIT and Harvard. …

Leukaemias and other cancers possess a rare population of cells capable of the limitless
self-renewal necessary for cancer initiation and maintenance 1 , 2 , 3 , 4 , 5 , 6 , 7 . Eradication …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized by …

Large panels of comprehensively characterized human cancer models, including the Cancer
Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study …

Most human epithelial tumors harbor numerous alterations, making it difficult to predict which
genes are required for tumor survival. To systematically identify cancer dependencies, we …

To enable arrayed or pooled loss-of-function screens in a wide range of mammalian cell
types, including primary and nondividing cells, we are developing lentiviral short hairpin RNA (…

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas 1 . Pre-clinical studies have demonstrated that the B-…