User profiles for W. A. Bickmore

W Bickmore

MRC Human Genetics Unit, University of Edinburgh
Verified email at igmm.ed.ac.uk
Cited by 29694

[HTML][HTML] Genome architecture: domain organization of interphase chromosomes

WA Bickmore, B Van Steensel - Cell, 2013 - cell.com
The architecture of interphase chromosomes is important for the regulation of gene expression
and genome maintenance. Chromosomes are linearly segmented into hundreds of …

The spatial organization of the human genome

WA Bickmore - Annual review of genomics and human genetics, 2013 - annualreviews.org
In vivo, the human genome functions as a complex, folded, three-dimensional chromatin
polymer. Understanding how the human genome is spatially organized and folded inside the …

Transcription factories: gene expression in unions?

H Sutherland, WA Bickmore - Nature Reviews Genetics, 2009 - nature.com
Transcription is a fundamental step in gene expression, yet it remains poorly understood at a
cellular level. Visualization of transcription sites and active genes has led to the suggestion …

Differences in the localization and morphology of chromosomes in the human nucleus

…, S Boyle, P Perry, P Teague, WA Bickmore - The Journal of cell …, 1999 - rupress.org
Using fluorescence in situ hybridization we show striking differences in nuclear position,
chromosome morphology, and interactions with nuclear substructure for human chromosomes …

The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells

…, NL Mahy, JA Ellis, WA Bickmore - Human molecular …, 2001 - academic.oup.com
To fully understand genome function, the linear genome map must be integrated with a
spatial map of chromosomes in the nucleus. Distinct nuclear addresses for a few human …

Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription

S Chambeyron, WA Bickmore - Genes & development, 2004 - genesdev.cshlp.org
The colinearity of genes in Hox clusters suggests a role for chromosome structure in gene
regulation. We reveal programmed changes in chromatin structure and nuclear organization …

[HTML][HTML] Single-cell dynamics of genome-nuclear lamina interactions

…, H Janssen, M Amendola, LD Nolen, WA Bickmore… - Cell, 2013 - cell.com
The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina
associated domains (LADs). The dynamics of these interactions and the relation to epigenetic …

[PDF][PDF] Chromatin motion is constrained by association with nuclear compartments in human cells

JR Chubb, S Boyle, P Perry, WA Bickmore - Current Biology, 2002 - cell.com
Background: In comparison with many nuclear proteins, the movement of chromatin in nuclei
appears to be generally constrained. These restrictions on motion are proposed to reflect …

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo

JF Armstrong, K Pritchard-Jones, WA Bickmore… - Mechanisms of …, 1993 - Elsevier
In the developing mouse, the Wilms' tumour gene, WT1, is first expressed in the intermediate
mesenchyme lateral to the coelomic cavity (13 somite, early 9 dpc embryo). A few hours …

[HTML][HTML] Recruitment to the nuclear periphery can alter expression of genes in human cells

…, E Kerr, P Perry, B Ylstra, JR Chubb, WA Bickmore - PLoS …, 2008 - journals.plos.org
The spatial organisation of the genome in the nucleus has a role in the regulation of gene
expression. In vertebrates, chromosomal regions with low gene-density are located close to …