Random walk is a fundamental concept with applications ranging from quantum physics to
econometrics. Remarkably, one specific model of random walks appears to be ubiquitous …

10.7554/eLife.09347.001 Cells can enter into a dormant state when faced with unfavorable
conditions. However, how cells enter into and recover from this state is still poorly understood…

Many bacteria on earth exist in surface-attached communities known as biofilms. These films
are responsible for manifold problems, including hospital-acquired infections and biofouling…

In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which
consists of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …

10.7554/eLife.23326.001 Upon fertilization, the genome of animal embryos remains
transcriptionally inactive until the maternal-to-zygotic transition. At this time, the embryo takes control …

Most bacteria at certain stages of their life cycle are able to move actively; they can swim in
a liquid or crawl on various surfaces. A typical path of the moving cell often resembles the …

10.7554/eLife.27240.001 In light microscopy, refractive index mismatches between media
and sample cause spherical aberrations that often limit penetration depth and resolution. …

We recorded large data sets of swimming trajectories of the soil bacterium Pseudomonas
putida. Like other prokaryotic swimmers, P. putida exhibits a motion pattern dominated by …

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two
major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and …

Histone post-translational modifications are key gene expression regulators, but their rapid
dynamics during development remain difficult to capture. We applied a Fab-based live …