Lynch syndrome, which is now recognized as the most common hereditary colorectal
cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Genetic epidemiology studies of colorectal cancer (CRC) can identify persons who are at
inordinately high risk and who thereby might benefit from targeted early detection and primary …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3% (∼30,700 cases) will have Lynch syndrome (LS), the most …

… The essays in part I focus on the premises of Lynch's work: his … In part II, excerpts from
Lynch's travel journals reveal his … This part of the book also presents Lynch's experiments with …

… ago, Aldred Scott Warthin, MD, PhD,[1] Chairman of the Department of Pathology at the
University of Michigan in Ann Arbor, reported the first family with the disease we now call Lynch …

Lynch syndrome (LS) is the most common of all inherited cancer syndromes, associated
with substantially elevated risks for colonic and extracolonic malignancies, earlier onset and …

ContextAbout 2% of all colorectal cancer occurs in the context of the autosomal dominantly
inherited Lynch syndrome, which is due to mutations in mismatch repair genes. Potential risk-…

… The Willie Lynch Letter This speech was said to have been delivered by Willie Lynch on
the bank of the James River in the colony of Virginia in 1712. Lynch was a British slave …

Background Women with the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
have a 40 to 60 percent lifetime risk of endometrial cancer and a 10 to 12 percent lifetime risk …

BACKGROUND Hereditary nonpolyposis colorectal cancer (HNPCC) dates to Aldred Warthin's
description of Family G a century ago. The phenotype features an excess of early onset …