[HTML][HTML] A plausible mechanism for auxin patterning along the developing root

…, NA Kolchanov, E Mjolsness, VA Likhoshvai - BMC systems …, 2010 - Springer
Background In plant roots, auxin is critical for patterning and morphogenesis. It regulates cell
elongation and division, the development and maintenance of root apical meristems, and …

Generalized Hill function method for modeling molecular processes

V Likhoshvai, A Ratushny - Journal of bioinformatics and …, 2007 - World Scientific
Development of an in silico cell is an urgent task of systems biology. The core of this cell
should consist of mathematical models of intracellular events, including enzymatic reactions …

Pathogenesis and treatment of HIV infection: the cellular, the immune system and the neuroendocrine systems perspective

…, B Bachmetyev, I Gainova, V Likhoshvai… - International reviews …, 2013 - Taylor & Francis
Infections with HIV represent a great challenge for the development of strategies for an effective
cure. The spectrum of diseases associated with HIV ranges from opportunistic infections …

Combined in silico/in vivo analysis of mechanisms providing for root apical meristem self-organization and maintenance

…, NA Kolchanov, E Mjolsness, VA Likhoshvai - Annals of …, 2012 - academic.oup.com
Background and Aims The root apical meristem (RAM) is the plant stem cell niche which
provides for the formation and continuous development of the root. Auxin is the main regulator …

Multiple scenarios of transition to chaos in the alternative splicing model

VV Kogai, VA Likhoshvai, SI Fadeev… - … Journal of Bifurcation …, 2017 - World Scientific
We have investigated the scenarios of transition to chaos in the mathematical model of a
genetic system constituted by a single transcription factor-encoding gene, the expression of …

GeneNet in 2005

…, DS Miginsky, VA Likhoshvai… - Nucleic Acids …, 2005 - academic.oup.com
The GeneNet system is designed for collection and analysis of the data on gene and
metabolic networks, signal transduction pathways and kinetic characteristics of elementary …

Chaos and hyperchaos in simple gene network with negative feedback and time delays

…, VV Kogai, SI Fadeev, VA Likhoshvai - … of Bioinformatics and …, 2017 - World Scientific
Today there are examples that prove the existence of chaotic dynamics at all levels of
organization of living systems, except intracellular, although such a possibility has been …

Alternative splicing can lead to chaos

VA Likhoshvai, VV Kogai, SI Fadeev… - … of bioinformatics and …, 2015 - World Scientific
Alternative splicing is a widespread phenomenon in higher eukaryotes, where it serves as a
mechanism to increase the functional diversity of proteins. This phenomenon has been …

On the chaos in gene networks

VA Likhoshvai, SI Fadeev, VV Kogai… - … of bioinformatics and …, 2013 - World Scientific
The methods for constructing "chaotic" nonlinear systems of differential equations modeling
gene networks of arbitrary structure and dimensionality with various types of symmetry are …

[HTML][HTML] Limit cycles in models of circular gene networks regulated by negative feedback loops

VA Likhoshvai, VP Golubyatnikov, TM Khlebodarova - BMC bioinformatics, 2020 - Springer
Background The regulatory feedback loops that present in structural and functional organization
of molecular-genetic systems and the phenomenon of the regulatory signal delay, a …