Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been
identified. This success, perhaps paradoxically, has posed challenges for therapeutic …

Background Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide
significant locus has been identified. We describe methods and procedures for the Anorexia …

Background Patients with follicular lymphoma can have long survival times, but disease
progression typically occurs 3–5 years after initial treatment. We assessed the potential benefit …

All organisms exposed to environmental stress conditions share a common molecular
response characterized by a dramatic change in the pattern of gene expression followed by an …

Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is
characterized by a striking degree of genetic and clinical heterogeneity. This heterogeneity …

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic
genetic architecture. However, little is known about how genetic variants impart brain …

Nucleation of aerosol particles from trace atmospheric vapours is thought to provide up to
half of global cloud condensation nuclei 1 . Aerosols can cause a net cooling of climate by …

Autism spectrum disorder (ASD) involves substantial genetic contributions. These contributions
are profoundly heterogeneous but may converge on common pathways that are not yet …

PURPOSE Ibrutinib has shown activity in non–germinal center B-cell diffuse large B-cell
lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …