The recent boom in microfluidics and combinatorial indexing strategies, combined with low
sequencing costs, has empowered single-cell sequencing technology. Thousands—or even …

Malignant tumors are characterized by structural and molecular peculiarities providing a
possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and …

Transcriptome sequencing is a powerful technique to study molecular changes that underlie
the differences in physiological conditions and disease progression. A typical question that …

We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …

The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative
cells are confined to crypts, while differentiated cell types predominantly occupy the villi. …

The great interest in photonic crystals and their applications in the last 15 years is being
expressed in the publishing of a large number of monographs, collections, textbooks and …

The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Mutations create variation in the population, fuel evolution and cause genetic diseases. Current
knowledge about de novo mutations is incomplete and mostly indirect 1 , 2 , 3 , 4 , 5 , 6 , …

A variety of mutational mechanisms shape the dynamic architecture of human genomes and
occasionally result in congenital defects and disease. Here, we used genome-wide long …