Background Conventional meta-analyses have shown inconsistent results for efficacy of
second-generation antidepressants. We therefore did a multiple-treatments meta-analysis, …

Background Major depressive disorder is one of the most common, burdensome, and costly
psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological …

Background Recent US and UK clinical practice guidelines recommend that second‐generation
antidepressants should be considered amongst the best first‐line options when drug …

Background The question of which antipsychotic drug should be preferred for the treatment
of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …

Objective To assess whether lithium has a specific preventive effect for suicide and self harm
in people with unipolar and bipolar mood disorders. Design Systematic review and meta-…

Background Schizophrenia is one of the most common, burdensome, and costly psychiatric
disorders in adults worldwide. Antipsychotic drugs are its treatment of choice, but there is …

BACKGROUND AND OBJECTIVES: Many reports of randomized controlled trials (RCTs)
fail to provide standard deviations (SDs) of their continuous outcome measures. Some meta-…

Rosaceae is the most important fruit-producing clade, and its key commercially relevant genera
(Fragaria, Rosa, Rubus and Prunus) show broadly diverse growth habits, fruit types and …

Background The benefits and safety of medications for attention-deficit hyperactivity disorder
(ADHD) remain controversial, and guidelines are inconsistent on which medications are …