Triazole substitution of a labile amide bond stabilizes pantothenamides and improves their antiplasmodial potency
VM Howieson, E Tran, A Hoegl, HL Fam… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The biosynthesis of coenzyme A (CoA) from pantothenate and the utilization of CoA in essential
biochemical pathways represent promising antimalarial drug targets. Pantothenamides, …
biochemical pathways represent promising antimalarial drug targets. Pantothenamides, …
[HTML][HTML] Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
…, AE Sexton, G Siddiqui, VM Howieson… - PLoS …, 2018 - journals.plos.org
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate
for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five …
for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five …
[HTML][HTML] Pantothenate biosynthesis in Toxoplasma gondii tachyzoites is not a drug target
VM Howieson, J Zeng, J Kloehn, C Spry… - International Journal for …, 2023 - Elsevier
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease
and death in immunocompromised individuals and the developing foetus. The treatment of …
and death in immunocompromised individuals and the developing foetus. The treatment of …
Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides
…, P Yang, T Kittikool, VM Howieson… - Journal of Medicinal …, 2021 - ACS Publications
Malaria-causing Plasmodium parasites are developing resistance to antimalarial drugs,
providing the impetus for new antiplasmodials. Although pantothenamides show potent …
providing the impetus for new antiplasmodials. Although pantothenamides show potent …
[HTML][HTML] A novel heteromeric pantothenate kinase complex in apicomplexan parasites
ET Tjhin, VM Howieson, C Spry, GG van Dooren… - PLoS …, 2021 - journals.plos.org
Coenzyme A is synthesised from pantothenate via five enzyme-mediated steps. The first
step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form …
step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form …
Structure–activity relationships of antiplasmodial pantothenamide analogues reveal a new way by which triazoles mimic amide bonds
J Guan, ET Tjhin, VM Howieson, T Kittikool… - …, 2018 - Wiley Online Library
Pantothenamides are potent growth inhibitors of the malaria parasite Plasmodium falciparum.
Their clinical use is, however, hindered due to the ubiquitous presence of pantetheinases …
Their clinical use is, however, hindered due to the ubiquitous presence of pantetheinases …
Mutations in the pantothenate kinase of the malaria parasite P. falciparum confer resistance or hypersensitivity to diverse pantothenate analogues
…, A Hoegl, L Barnard, AE Sexton, VM Howieson… - bioRxiv, 2017 - biorxiv.org
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate
for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five …
for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five …
Triazole substitution of the pantetheinase-sensitive amide bond stabilizes pantothenamides and improves their antiplasmodial potency
VM Howieson, E Tran, A Hoegl, HL Fam, J Fu… - 2016 - escholarship.mcgill.ca
MATERIALS AND METHODS Parasite culture. P. falciparum parasites (strain 3D7) at the
red blood cell stage were maintained in continuous culture using an adaptation (19) of a …
red blood cell stage were maintained in continuous culture using an adaptation (19) of a …
Asynchronous regional brain volume losses in presymptomatic to moderate AD
…, J Quinn, R Camicioli, D Howieson… - Journal of …, 2005 - content.iospress.com
To determine if rates and locations of brain volume loss associated with AD are phase-specific,
occurring prior to clinical onset and at later stages, we performed longitudinal volumetric …
occurring prior to clinical onset and at later stages, we performed longitudinal volumetric …
Advances in Rhizobium research
A Sessitsch, JG Howieson, X Perret… - Critical Reviews in …, 2002 - Taylor & Francis
… soils in the Mediterranean basin (Howieson and Ewing, 1986) combined with species of
Medicago more capable of nodulation under acid stress (Howieson and Ewing, 1989) allowed …
Medicago more capable of nodulation under acid stress (Howieson and Ewing, 1989) allowed …