Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …

… Gaidzik, Marianne Habdank, Jan Krönke, Lars Bullinger, Daniela Späth, Sabine Kayser,
Manuela Zucknick, Katharina Götze, Heinz-A. Horst, Ulrich Germing, Hartmut Döhner, and …

To assess the frequency of TP53 alterations and their correlation with other genetic changes
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …

B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the
mitochondrion. It remains a challenge to identify those tumors that are best treated by …

In recent years, research in molecular genetics has been instrumental in deciphering the
molecular pathogenesis of acute myeloid leukemia (AML). With the advent of the novel …

… Gaidzik, Peter Paschka, Shiva Onken, Karina Eiwen, Marianne Habdank, Daniela Späth,
Michael Lübbert, Mohammed Wattad, Thomas Kindler, Helmut R. Salih, Gerhard Held, David …

The objective was to evaluate the prognostic and predictive impact of allelic ratio and insertion
site (IS) of internal tandem duplications (ITDs), as well as concurrent gene mutations, with …

… Gaidzik et al … Gaidzik et al … Paschka P, Schlenk RF, Gaidzik VI, et al: IDH1 and IDH2
mutations are frequent genetic alterations in acute myeloid leukemia (AML) and confer …

We evaluated the frequency, genetic architecture, clinico-pathologic features and prognostic
impact of RUNX1 mutations in 2439 adult patients with newly-diagnosed acute myeloid …

Purpose The tet oncogene family member 2 (TET2) gene was recently identified to be mutated
in myeloid disorders including acute myeloid leukemia (AML). To date, there is increasing …