Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

The Gadd45 proteins have been intensively studied, in view of their important role in key
cellular processes. Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by …

Understanding the genetic basis of human longevity remains a challenge but could lead to
life-extending interventions and better treatments for age-related diseases. Toward this end …

The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info ) is a freely
available online collection of research databases and tools for the biology and genetics of …

In spite of a growing body of research and data, human ageing remains a poorly understood
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR)…

Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many …

… thank AIT - Austrian Institute of Technology and specifically, Manuela Hofner, for their help
in deriving the cells from lung biopsies and delivery of cell cultures from Vienna to Fraifeld's …

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds
that extend lifespan in model organisms is a growing research area. Here, we present …

The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging
topic in aging research. Our comprehensive data mining revealed over 250 genes tightly …

As the level of interest in aging research increases, there is a growing number of geroprotectors,
or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce …