… The on-target nucleotide within the LMNA transcript was efficiently (more than 80%) corrected
from U to C in ABE-treated cells (Fig. 2b). The average frequency and distribution of A-to-I …

Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature
aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized
by premature death from myocardial infarction or stroke. It is caused by de novo single…

The high-throughput detection of organelle composition and proteomic mapping of protein
environment directly from primary tissue as well as the identification of interactors of insoluble …

Hematological parameters, including red and white blood cell counts and hemoglobin
concentration, are widely used clinical indicators of health and disease. These traits are tightly …

Hutchinson‐Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder most
notably characterized by cardiovascular disease and premature death from myocardial …

Asthma is etiologically and clinically heterogeneous, making the genomic basis of asthma
difficult to identify. We exploited the strain-dependence of a murine model of allergic airway …

Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder affecting
tissues of mesenchymal origin. Most individuals with HGPS harbor a de novo c.1824C > T (p.…

Identification of protein-protein interactions is a major goal of biological research. Despite
technical advances over the last two decades, important but still largely unsolved challenges …

We aim to identify interactions between genes and allergen exposure that are relevant to
the development of asthma in humans using a mouse model. To accomplish this, we first …