User profiles for U. Schulze-Gahmen
 | Ursula Schulze-GahmenVerified email at gladstone.ucsf.edu Cited by 5140 |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …
[PDF][PDF] Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
…, S Miller, B Sreekumar, PY Chen, U Schulze-Gahmen… - Cell, 2021 - cell.com
We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …
Structural evidence for induced fit as a mechanism for antibody-antigen recognition
JM Rini, U Schulze-Gahmen, IA Wilson - Science, 1992 - science.org
The three-dimensional structure of a specific antibody (Fab 17/9) to a peptide immunogen
from influenza virus hemagglutinin [HA1(75-110)] and two independent crystal complexes of …
from influenza virus hemagglutinin [HA1(75-110)] and two independent crystal complexes of …
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
…, U Schulze-Gahmen… - Proceedings of the …, 1996 - National Acad Sciences
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a
promising target for studying inhibitory molecules that can modify the degree of cell …
promising target for studying inhibitory molecules that can modify the degree of cell …
[HTML][HTML] Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation
…, B Sreekumar, PY Chen, U Schulze-Gahmen… - MedRxiv, 2021 - ncbi.nlm.nih.gov
We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172
nasal/nasopharyngeal swab samples from 44 counties in California. Named B. 1.427/B. 1.429 to …
nasal/nasopharyngeal swab samples from 44 counties in California. Named B. 1.427/B. 1.429 to …
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–…
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–…
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design
U Schulze-Gahmen, HL De Bondt… - Journal of medicinal …, 1996 - ACS Publications
Inhibition of the cell cycle is widely considered as a new approach toward treatment for
diseases caused by unregulated cell proliferation, including cancer. Since cyclin-dependent …
diseases caused by unregulated cell proliferation, including cancer. Since cyclin-dependent …
Multiple modes of ligand recognition: crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and …
U Schulze‐Gahmen, J Brandsen… - Proteins: Structure …, 1995 - Wiley Online Library
Cyclin‐dependent kinases (CDKs) are conserved regulators of the eukaryotic cell cycle with
different isoforms controlling specific phases of the cell cycle. Mitogenic or growth inhibitory …
different isoforms controlling specific phases of the cell cycle. Mitogenic or growth inhibitory …
[HTML][HTML] CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but
its exact functions, and the structural basis of those functions, remain unknown. Here, we …
its exact functions, and the structural basis of those functions, remain unknown. Here, we …
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
…, B Baratte, L Meijer, U Schulze-Gahmen - Journal of medicinal …, 2005 - ACS Publications
Cyclin-dependent kinases (CDKs) play a central role in cell cycle control, apoptosis,
transcription, and neuronal functions. They are important targets for the design of drugs with …
transcription, and neuronal functions. They are important targets for the design of drugs with …