Can a heterotrophic organism be evolved to synthesize biomass from CO 2 directly? So far,
non-native carbon fixation in which biomass precursors are synthesized solely from CO 2 …

Most genes change expression levels across conditions, but it is unclear which of these
changes represents specific regulation and what determines their quantitative degree. Here, we …

Turnover numbers, also known as k cat values, are fundamental properties of enzymes.
However, k cat data are scarce and measured in vitro, thus may not faithfully represent the in …

Protein levels are a dominant factor shaping natural and synthetic biological systems. Although
proper functioning of metabolic pathways relies on precise control of enzyme levels, the …

Translational coupling is the interdependence of translation efficiency of neighboring genes
encoded within an operon. The degree of coupling may be quantified by measuring how the …

10.7554/eLife.20667.001 A set of chemical reactions that require a metabolite to synthesize
more of that metabolite is an autocatalytic cycle. Here, we show that most of the reactions in …

Understanding the evolution of a new metabolic capability in full mechanistic detail is
challenging, as causative mutations may be masked by non-essential "hitchhiking" mutations …

Most proteins show changes in level across growth conditions. Many of these changes seem
to be coordinated with the specific growth rate rather than the growth environment or the …

… E-mail: uri.barenholz@gmail.com. … Let G1 be a graph on 9 vertices u, v1,w1,...,v4,w4,
in which vertex u is connected by a star to vertices v1,...,v4, and for every 1 ≤ i ≤ 4, vi is …

Most proteins show changes in level across growth conditions. Many of these changes seem
to be coordinated with the growth rate rather than the specific environment or the protein …