Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map
these lesions genome-wide with nucleotide-level precision are limited. Here, we present a …

… T lymphocytes depend on transcription from hypervariable regions. To generate variability,
T … in the variable regions of immunoglobulin and T cell receptor genes. Activation-induced …

… form of SV40 large T antigen (SV40ts58). Comparisons were made to wild-type SV40
large T antigen-expressing cells and to cells expressing SV40ts58 large T antigen grown to …

… To investigate this in more detail, we repeated the experiment with LNA-U in place of LNA-T
at position 10. This new compound displayed activity similar to the unmodified siRNA (…

… value) for NA and for HI in the absence a ed for statistical significance using Student's t-test. …
he peptides evoked a maximum contractile response ex ed by high K + (Wahlestedt and H~…

… However, the increase in BACE1 mRNA was not statistically significant in cerebellum and
hippocampus (unpaired t-test with Welch's correction: ns = not significant; *P-value < 0.05; **P-…

Antisense transcription (transcription from the opposite strand to a protein-coding or sense
strand) has been ascribed roles in gene regulation involving degradation of the …

Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG-…

We propose a search engine and file retrieval system for all bioinformatics databases
worldwide. PubData searches biomedical data in a user-friendly fashion similar to how PubMed …

… this finding might be related to a recently described T1128C coding polymorphism which
results in a Leu7-> Pro7 substitution of the signal peptide, and a previously not described T -…