It is now nearly 5 years since the last of the currently recognised 5-HT receptors was identified
in terms of its cDNA sequence. Over this period, much effort has been directed towards …

… This is a sharp contrast to the lower coverage used with capillary-based sequencing, where
algorithms were frequently confronted with regions having very low amounts of data. Thus, …

Phytophthora infestans is the most destructive pathogen of potato and a model organism for
the oomycetes, a distinct lineage of fungus-like eukaryotes that are related to organisms …

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The
genome is relatively repetitive but has little segmental duplication. Chromosomes appear to …

… C, centromeric; I, interstitial; T, telomeric. P values were computed using a two-sided t-test …
P values calculated using a two-tailed paired two-sample t-test for the 14 categories from a. c, d…

… In genealogies 1 (dashed line), 2, and 3, all coalescence events are ancient and occur
before time T znb . b, Phylogenetic analysis of RAD-sequence data showing well-supported …

We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis
domestica). As the first metatherian (‘marsupial’) species to be sequenced, the …

Domestic animals are excellent models for genetic studies of phenotypic evolution 1 , 2 , 3 .
They have evolved genetic adaptations to a new environment, the farm, and have been …

Mechanistic information and structure-based design methods have been used to design a
series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (…

Background The process of generating raw genome sequence data continues to become
cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished …